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NQO1 substrate

Name: NQO1 substrate
Brand: TargetMol
SKU: T13799
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13799Cas No. 2304503-05-5

NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.

NQO1 substrate

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Purity: 98.02%

Catalog No. T13799Cas No. 2304503-05-5

NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	-	In Stock
2 mg	$52	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.02%

Appearance:Solid

Color:Yellow

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COA HPLC

Product Introduction

NQO1 substrate AI Summary

NQO1 substrate exhibits various bioactivities, including cytotoxicity against multiple cell lines expressing NQO1, with IC50 values ranging from 1000.0 nM to 33200.0 nM. It acts as a substrate for recombinant human NQO1, inducing ROS generation and demonstrating a Kcat/Km ratio of 6.2 x 10^6/M/s. The compound induces apoptosis in NQO1-expressing cells, leading to changes in the percentages of viable, necrotic, early, and late apoptotic cells at different concentrations and treatments. Additionally, NQO1 substrate has demonstrated antitumor activity in NQO1-expressing xenografted mice, evidenced by reductions in tumor volume and weight, and shows selectivity in its cytotoxic effects against NQO1-expressing cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.

Chemical Properties

Molecular Weight	268.18
Formula	C₁₃H₂F₂N₄O
Cas No.	2304503-05-5
Smiles	Fc1cc2C(=O)c3nc(C#N)c(nc3-c2cc1F)C#N
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (372.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7288 mL	18.6442 mL	37.2884 mL	186.4419 mL
5 mM	0.7458 mL	3.7288 mL	7.4577 mL	37.2884 mL
10 mM	0.3729 mL	1.8644 mL	3.7288 mL	18.6442 mL
20 mM	0.1864 mL	0.9322 mL	1.8644 mL	9.3221 mL
50 mM	0.0746 mL	0.3729 mL	0.7458 mL	3.7288 mL
100 mM	0.0373 mL	0.1864 mL	0.3729 mL	1.8644 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc