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B220
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Synonyms:
Catalog No. T10445 Copy Product Info
Purity: 99.9%
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B220 is an indoloquinoline antiviral agent that inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV). B220 exhibits antiviral and immunomodulatory activity.
Cas No. 112228-65-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $178 | In Stock | In Stock | |
| 5 mg | $447 | In Stock | In Stock | |
| 10 mg | $592 | In Stock | In Stock | |
| 25 mg | $894 | In Stock | In Stock | |
| 50 mg | $1,180 | In Stock | In Stock | |
| 100 mg | $1,650 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $442 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.9%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | B220 is an indoloquinoline antiviral agent that inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV). B220 exhibits antiviral and immunomodulatory activity. |
| In vitro | Methods: Add 3 μM B220 to HCT116 colorectal cancer cells and treat for 6, 12, 24, or 48 hours. Detect cell cycle progression via PI staining and flow cytometry. Results: 6–24 hours: Cells significantly accumulated in the G2/M phase. 48 hours: Sub-G1 phase cells (apoptosis peak) significantly increased. [1] Methods: Human neutrophils were pretreated with B220 (5, 10 μg/mL) for 5 min, then stimulated with serum-conditioned yeast particles (PMA) (5×10⁻⁸ M). Chemiluminescence signals were continuously recorded post-stimulation (approx. 30–60 min) using luminol-enhanced chemiluminescence (containing SOD and catalase to detect intracellular ROS). Results: B220 dose-dependently inhibited PMA- and calyptra-induced intracellular ROS production. [2] |
| Molecular Weight | 318.42 |
| Formula | C20H22N4 |
| Cas No. | 112228-65-6 |
| Smiles | CN(C)CCn1c2ccccc2c2nc3cc(C)c(C)cc3nc12 |
| Relative Density. | 1.18 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (28.26 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: B220 chemical structure | B220 in vitro | B220 formula | B220 molecular weight
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