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MM41

Name: MM41
Brand: TargetMol
SKU: T60028
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60028Cas No. 1429028-96-5

MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.

MM41

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Purity: 99.25%

Catalog No. T60028Cas No. 1429028-96-5

MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$118	-	In Stock
10 mg	$188	-	In Stock
25 mg	$308	-	In Stock
50 mg	$413	-	In Stock
100 mg	$548	-	In Stock
200 mg	$749	-	In Stock
1 mL x 10 mM (in DMSO)	$163	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.25%

Appearance:Solid

Color:Blue

Resource Download

COA LCMS HNMR

Product Introduction

MM41 AI Summary

MM41 induces senescence in human MIAPaCa2 cells and modulates gene expression by downregulating SLX4, RASSF1, and PTEGES3, while upregulating PRKCB, PPARG, NHP2, and MYC genes. It exhibits cytotoxicity against various human cell lines such as PANC1, MIAPaCa2, MCF7, and A549, with varying IC50 values from 3.0 nM to 230.0 nM. Specifically, it has an IC50 value of 3.0 nM after 96 hours in human PANC1 cells, as determined by the SRB assay. In vivo studies show that the compound demonstrates antitumor activity against MIAPaCa2 xenografts in CD-1 nude mice, achieving significant reductions in tumor volume when administered at 15 mg/kg intravenously twice weekly for 4 weeks, though toxicity emerges at a maximum tolerated dose of 25.0 mg/kg. Additionally, MM41 selectively binds to various G-quadruplex RNA and DNA structures, including the human telomeric G-quadruplex and TERT hairpin duplex DNA, exhibiting binding affinities with dissociation equilibrium constants ranging from 2.0 nM to 10.0 nM. It stabilizes the promoter sequences of HSP90a and HSP90b, as well as the human telomeric G-quadruplex, indicated by significant changes in melting temperatures. These stabilizing effects vary, causing melting temperature increases from 4.9°C to 33.1°C for different DNA structures, and a reduced melting temperature change of less than 2.0°C for TERT hairpin duplex DNA. Such properties suggest its broad potential in cancer therapy, providing differential cytotoxic and binding activities that could be leveraged against diverse cell lines and DNA structures..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.

Chemical Properties

Molecular Weight	831.06
Formula	C₄₄H₆₆N₁₀O₆
Cas No.	1429028-96-5
Smiles	CN1CCN(CCCNc2cc3c4c(c(NCCCN5CCN(C)CC5)cc5c4c2c(=O)n(CCCN2CCOCC2)c5=O)c(=O)n(CCCN2CCOCC2)c3=O)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (36.1 mM), when pH is adjusted to 8 with HCl. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2033 mL	6.0164 mL	12.0328 mL	60.1641 mL
5 mM	0.2407 mL	1.2033 mL	2.4066 mL	12.0328 mL
10 mM	0.1203 mL	0.6016 mL	1.2033 mL	6.0164 mL
20 mM	0.0602 mL	0.3008 mL	0.6016 mL	3.0082 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc