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Clomipramine hydrochloride

Name: Clomipramine hydrochloride
Brand: TargetMol
SKU: T0255
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0255Cas No. 17321-77-6

Alias Clomipramine HCl, Anafranil

Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Clomipramine hydrochloride

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Purity: 99.47%

Catalog No. T0255Alias Clomipramine HCl, AnafranilCas No. 17321-77-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$33	In Stock	-
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Clomipramine hydrochloride AI Summary

Clomipramine hydrochloride exhibits a diverse range of bioactivities. It shows significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 5011.87 nM to 10000.0 nM after 72 hours in a SYBR green assay. The compound demonstrates antiviral properties, including inhibition of SARS-CoV-2 replication in Vero E6 cells with IC50 values of 5630.0 nM at MOI 0.004 and 7590.0 nM at MOI 0.01, and no significant cytotoxic effects at CC50 values above 29680.0 nM. Additionally, it inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells and Vero-6 cells at 10 µM concentration. Clomipramine hydrochloride also inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells with 78.81% and 43.58% inhibition, respectively, at 10 µM concentration. Moreover, Clomipramine hydrochloride exhibits moderate antibacterial and antifungal activities against various microbial strains, including a 30.63% inhibition against Acinetobacter baumannii ATCC 19606. It shows modest cytotoxicity against human HepG2 cells with an IC50 value of 6500.0 nM. The compound also demonstrates inhibition of Influenza NS1 protein function, activity against JMJD2E enzyme, and potential modulation of splicing of Lamin A and SMN2 splice variants. Additionally, it acts as an antagonist to the Neuropeptide S receptor, activator of Cytochrome P450 3A4, and inhibits other biological processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Targets&IC50	Dopamine transporter:3 nM(Ki), NET:54 nM(Ki), SERT:0.14 nM(Ki)
Synonyms	Clomipramine HCl, Anafranil

Chemical Properties

Molecular Weight	351.31
Formula	C₁₉H₂₃ClN₂·HCl
Cas No.	17321-77-6
Smiles	Cl.CN(C)CCCN1c2ccccc2CCc2c1cc(Cl)cc2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 142.32 mM, Sonication is recommended.

DMSO: 7.5 mg/mL (21.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8465 mL	14.2324 mL	28.4649 mL	142.3244 mL
5 mM	0.5693 mL	2.8465 mL	5.6930 mL	28.4649 mL
10 mM	0.2846 mL	1.4232 mL	2.8465 mL	14.2324 mL
20 mM	0.1423 mL	0.7116 mL	1.4232 mL	7.1162 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0569 mL	0.2846 mL	0.5693 mL	2.8465 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4232 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc