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Anti-Antithrombin III Antibody (1P791)
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Catalog No. TMAY-00337
Alias SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Anti-Antithrombin III Antibody (1P791) is a Rabbit antibody targeting Antithrombin III. Anti-Antithrombin III Antibody (1P791) can be used in ELISA.
Anti-Antithrombin III Antibody (1P791)
Anti-Antithrombin III Antibody (1P791)
😃Good
Catalog No. TMAY-00337Alias SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Anti-Antithrombin III Antibody (1P791) is a Rabbit antibody targeting Antithrombin III. Anti-Antithrombin III Antibody (1P791) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Antithrombin III Antibody (1P791) is a Rabbit antibody targeting Antithrombin III. Anti-Antithrombin III Antibody (1P791) can be used in ELISA. |
| Alias | SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1P791 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Antithrombin III / ATIII / SerpinC1 (rh Antithrombin III / ATIII / SerpinC1; TMPY-00916; NP_000479.1; Met 1-Lys 464). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Serpin C1 protein (TMPY-00916) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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