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Dehydroabietic acid

Name: Dehydroabietic acid
Brand: TargetMol
SKU: TCS1772
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TCS1772Cas No. 1740-19-8

Alias Dehydroabietate

1. Dehydroabietic acid (Dehydroabietate) (DAA) is an EBV-EA activation inhibitor. 2. DAA is a useful food-derived compound for treating obesity-related diseases, by decreasing plasma glucose, insulin levels, plasma triglyceride (TG) , and hepatic TG levels. 3. DAA derivatives displays anti-secretory and anti-pepsin effect in animal models.

Dehydroabietic acid

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Purity: 99.80%

Catalog No. TCS1772Alias DehydroabietateCas No. 1740-19-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$183	In Stock	In Stock
50 mg	$276	-	In Stock
100 mg	$397	-	In Stock
500 mg	$937	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Dehydroabietic acid AI Summary

Dehydroabietic acid exhibits a range of bioactivities against various viruses, bacteria, fungi, and cancer cell lines. It shows potent antiviral activity with an IC50 value of 20.0 μg/mL against herpes simplex virus 2 (HSV-2) in Vero cells and significantly inhibits Epstein-Barr virus early antigen activation in human Raji cells, with inhibition rates increasing as molar ratios relative to TPA decrease. The compound displays antimicrobial properties with MIC values of 12.5 μg/mL against Staphylococcus aureus, including methicillin-resistant strains, and inhibitory effects at higher concentrations against Bacillus subtilis, Escherichia coli, and Pseudomonas fluorescens. Additionally, it demonstrates antifungal activity against Trametes versicolor, Gloeophyllum trabeum, and Aspergillus terreus. In antiinflammatory assays, Dehydroabietic acid inhibits LPS-induced NO release in mouse RAW264.7 cells with an IC50 value of 42.7 μg/mL. Cytotoxicity assays reveal its potent effects against multiple cancer cell lines, including HeLa, HCT116, SKOV3, HepG2, and NCI-H460, with IC50 values ranging from approximately 29,350 nM to over 100,000 nM, suggesting potential anticancer properties. Furthermore, the compound exhibits antiangiogenic activity by reducing tube formation in HUVEC cells and neuroprotective activity in rat C6 cells by inducing NGF release. Lastly, Dehydroabietic acid's antibiofilm and antiproliferative activities make it effective in inhibiting biofilm formation in Staphylococcus aureus and preferentially cytotoxic against human MIA PaCa-2 cells in nutrient-deprived conditions. These multifaceted bioactivities highlight Dehydroabietic acid's potential for therapeutic applications across various domains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Dehydroabietic acid (Dehydroabietate) (DAA) is an EBV-EA activation inhibitor. 2. DAA is a useful food-derived compound for treating obesity-related diseases, by decreasing plasma glucose, insulin levels, plasma triglyceride (TG) , and hepatic TG levels. 3. DAA derivatives displays anti-secretory and anti-pepsin effect in animal models.
Synonyms	Dehydroabietate

Chemical Properties

Molecular Weight	300.44
Formula	C₂₀H₂₈O₂
Cas No.	1740-19-8
Smiles	C[C@@]12[C@]([C@@](C(O)=O)(C)CCC1)(CCC=3C2=CC=C(C(C)C)C3)[H]
Relative Density.	1.058g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 125 mg/mL (416.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3285 mL	16.6423 mL	33.2845 mL	166.4226 mL
5 mM	0.6657 mL	3.3285 mL	6.6569 mL	33.2845 mL
10 mM	0.3328 mL	1.6642 mL	3.3285 mL	16.6423 mL
20 mM	0.1664 mL	0.8321 mL	1.6642 mL	8.3211 mL
50 mM	0.0666 mL	0.3328 mL	0.6657 mL	3.3285 mL
100 mM	0.0333 mL	0.1664 mL	0.3328 mL	1.6642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc