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IP7e

Name: IP7e
Brand: TargetMol
SKU: T27620
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27620Cas No. 500164-74-9

Alias isoxazolo-pyridinone 7e, IP-7e, IP 7e

IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM.

IP7e

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Purity: 99.86%

Catalog No. T27620Alias isoxazolo-pyridinone 7e, IP-7e, IP 7eCas No. 500164-74-9

IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$172	In Stock
25 mg	$396	In Stock
50 mg	$649	In Stock
100 mg	$987	In Stock
200 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock

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Batch Information

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Purity:99.86%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM.
Targets&IC50	Nurr1:3.9 nM(EC50)
In vivo	IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE)[1].
Synonyms	isoxazolo-pyridinone 7e, IP-7e, IP 7e

Chemical Properties

Molecular Weight	390.43
Formula	C₂₃H₂₂N₂O₄
Cas No.	500164-74-9
Smiles	COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (243.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5613 mL	12.8064 mL	25.6128 mL	128.0639 mL
5 mM	0.5123 mL	2.5613 mL	5.1226 mL	25.6128 mL
10 mM	0.2561 mL	1.2806 mL	2.5613 mL	12.8064 mL
20 mM	0.1281 mL	0.6403 mL	1.2806 mL	6.4032 mL
50 mM	0.0512 mL	0.2561 mL	0.5123 mL	2.5613 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	1.2806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc