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Steroids

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes which alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi.

  • Digitonin
    T272111024-24-1
    Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of cell membranes in a wide range of cells.
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  • Caudatin
    T315038395-02-7
    Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities.
    • $84
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  • Protodioscin
    T232155056-80-9
    Protodioscin (Furostanol I) is a major steroidal saponin in dioscoreae rhizome, with anti-hyperlipidemia, anti-cancer properties.
    • $110
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  • Testosterone phenylpropionate
    T31301255-49-8
    Testosterone phenylpropionate (Testosterone 17-phenylpropionate)is a steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.
    • $50
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  • Cortodoxone
    T2748152-58-9
    Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
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  • Asiatic acid
    T2827464-92-6
    Asiatic acid (Dammarolic acid) is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties.
    • $30
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  • Cholesteryl Acetate
    T2918604-35-3
    Cholesteryl Acetate is a cholesterol ester obtained from the esterification of the hydroxyl group of cholesterol with acetic acid. It functions as a metabolite in the human body and is both a cholesterol ester and an acetate ester.
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  • Cholic Acid
    T296381-25-4
    Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.
    • $34
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  • Dioscin
    T647319057-60-4
    Dioscin (Collettiside III) is a saponin with antitumor activities.
    • $50
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  • Cortisone
    T288453-06-5
    Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity.
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  • Deoxycholic acid sodium salt
    T5077302-95-4
    Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
    • $38
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  • Pseudoprotodioscin
    T5S0246102115-79-7
    1. Pseudoprotodioscin has moderate cytotoxicity.
    • $130
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  • Sarsasapogenin
    T2733126-19-2
    Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing plants found in subtropical regions. It was one of the first sapogenins to be identified, and the first spirostan steroid to be identified as such.
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  • Estradiol
    T104850-28-2
    Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
    • $30
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  • Crustecdysone
    T28815289-74-7
    Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.
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  • Bufotalin
    T5A2461471-95-4
    1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.
    • $40
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  • Lithocholic acid
    T2202434-13-9
    Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
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  • Glycoursodeoxycholic acid
    T523464480-66-6
    Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.
    • $50
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  • 2-Methoxyestradiol
    T2220362-07-2
    2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
    • $50
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  • Stigmasterol
    T296783-48-7
    Stigmasterol (Stigmasterin) is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk. Stigmasterol has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
    • $55
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  • Androsterone
    T526453-41-8
    Androsterone, a metabolic product of testosterone, can activate Farnesoid X Receptor (FXR).
    • $46
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  • Adrenosterone
    T2207382-45-6
    Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
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  • Ergostenol
    TN7070632-32-6
    Ergostenol (Ergost-8(14)-en-3beta-ol) is a biological precursor and a provitamin of vitamin D2.
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  • Telocinobufagin
    T4A2462472-26-4
    1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice challenged with live S. typhimurium. 3. Telocinobufagin has immunomodulatory activity, can enhance a Th1 immune response to control intracellular infections, could be developed as a novel immunotherapeutic agent to treat cancer and other immune-mediated diseases.
    • $57
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  • Epiandrosterone
    T2195481-29-8
    Epiandrosterone (EpiA) is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
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    • Terrestrosin D
      T2S0886179464-23-4
      Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and an
      • $35
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    • Deoxycholic acid
      T296583-44-3
      Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
      • $53
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    • GLYCODEOXYCHOLIC ACID
      T5352360-65-6
      Glycodeoxycholic Acid is an endogenous metabolite, a natural product found in Streptomyces niger, Trypanosoma brucei, and Cryptomonas, which induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
      • $30
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    • Progesterone
      T047857-83-0
      Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
      • $38
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    • Cholesterol
      T076057-88-5
      Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
      • $45
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    • Cinobufagin
      T3432470-37-1
      Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.
      • $44
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    • Polyphyllin VI
      T6S231555916-51-3
      1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.
      • $140
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    • Oleandrin
      T5S0890465-16-7
      1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
      • $98
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    • Hecogenin
      T4878467-55-0
      Hecogenin (Hocogenin), a steroid saponin derived from Agave sisalana, serves as a specific inhibitor for human UDP-glucuronosyltransferases. Notably, it exhibits a broad range of pharmacological activities, such as anti-inflammatory, antifungal, and gastroprotective effects[1].
      • $31
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    • WITHAFERIN A
      T56875119-48-2
      WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.
      • $77
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    • 25-Hydroxycholesterol
      T47172140-46-7
      25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis
      • $45
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    • Hyodeoxycholic acid
      T296883-49-8
      Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
      • $38
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    • Polyphyllin I
      T389550773-41-6
      Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
      • $52
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    • Taurocholic acid
      TN225981-24-3
      Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
      • $55
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    • Campesterol
      T4S2157474-62-4
      Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory effect, it inhibits several pro-inflammatory and matrix degradation mediators typically involved in osteoarthritis- induced cartilage degradation, also sometimes used to treat some specific prostate conditions.
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    • Cholesteryl sulfate sodium
      T52392864-50-8
      Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a regulatory function. Cholesteryl sulfate sodium also activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.
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    • Glycocholic acid
      T2831475-31-0
      Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways.
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    • Chenodeoxycholic acid
      T0847474-25-9
      Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
      • $55
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    • Bufalin
      T1719465-21-4
      Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic a
      • $55
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    • Hydrocortisone
      T161450-23-7
      Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses.
      • $30
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    • 3,5,6-trihydroxysitostane
      T84308133697-68-4
      3,5,6-trihydroxysitostane is a steroid natural product derived from the fruits of Evodia rutaecarpa.
      • $195
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    • Precyasterone
      T3S023727335-85-9
      Precyasterone is a natural compound extracted from the dried roots of Cyathula capitata.
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    • Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside
      T3S1250128502-94-3
      Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside) is a natural product, and has good pharmacological effects on the cardiovascular system.
      • $152
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    • Etiocholanolone
      TN676553-42-9
      Etiocholanolone (Etiocholanone) (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form.
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      • Qingyangshengenin
        T702484745-94-8
        Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.
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