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Anti-Titin Polyclonal Antibody
(Synonyms: TTN, Titin, Rhabdomyosarcoma antigen MU-RMS-40.14, Connectin) Copy Product Info
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Synonyms: TTN, Titin, Rhabdomyosarcoma antigen MU-RMS-40.14, Connectin
Catalog No. TMAB-01848 Copy Product Info
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Anti-Titin Polyclonal Antibody is a Rabbit antibody targeting Titin. Anti-Titin Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P.
Anti-Titin Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Titin Polyclonal Antibody is a Rabbit antibody targeting Titin. Anti-Titin Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P. |
| Synonyms | TTN, Titin, Rhabdomyosarcoma antigen MU-RMS-40.14, Connectin |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Pig,Cow) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200; FCM: 1ug/test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Isoform 3, isoform 7 and isoform 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in cardiac tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Titin, also known as connectin, is a large protein involved in the temporal and spatial control of the assembly of the highly ordered sarcomeres (contractile units) of striated muscle. In addition to sarcomere assembly Titin also functions to maintain the structural integrity of the contracting myofibrils within the muscle and to organize the machinery for condensation of chromosomes in dividing cells. Titin is a giant protein composed of 27,000 amino acids and contains an autoregulated serine kinase catalytic domain as well as a calcium/calmodulin binding region that are involved in its activation. Activated Titin phosphorylates the muscle protein telethonin, a sarcomeric protein abundant in heart and skeletal muscle, implicating Titin activity in the reorganization of the cytoskeleton during myofibrillogenesis. |
| Immunogen | KLH conjugated synthetic peptide: human Titin/CMD1G |
| Antigen Species | Human |
| Gene Name | TTN |
| Gene ID | |
| Protein Name | Titin |
| Uniprot ID | |
| Biology Area | Actins,Myosins,Hypertrophy,Chromosome,Actin Binding Proteins,Myosin |
| Function | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. |
| Molecular Weight | Theoretical: 3780 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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