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A 1070722

Name: A 1070722
Brand: TargetMol
SKU: T10202
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10202Cas No. 1384424-80-9

A 1070722 is a potent and selective GSK-3 inhibitor, exhibiting high affinity for both GSK-3α (Ki = 0.6 nM) and GSK-3β (Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulate in brain regions, indicating potential use as a PET radiotracer for quantifying GSK-3 in the brain.

A 1070722

🥰Excellent

Purity: 99.9%

Catalog No. T10202Cas No. 1384424-80-9

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$58	In Stock
25 mg	$118	In Stock
50 mg	$213	In Stock
100 mg	$320	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.9%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	A 1070722 is a potent and selective GSK-3 inhibitor, exhibiting high affinity for both GSK-3α (Ki = 0.6 nM) and GSK-3β (Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulate in brain regions, indicating potential use as a PET radiotracer for quantifying GSK-3 in the brain.
Targets&IC50	GSK-3β:0.6 nM (ki), GSK-3α:0.6 nM (ki)
In vivo	PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain[1].

Chemical Properties

Molecular Weight	362.31
Formula	C₁₇H₁₃F₃N₄O₂
Cas No.	1384424-80-9
Smiles	COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1
Relative Density.	1.461 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (230.00 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7601 mL	13.8003 mL	27.6007 mL	138.0034 mL
5 mM	0.5520 mL	2.7601 mL	5.5201 mL	27.6007 mL
10 mM	0.2760 mL	1.3800 mL	2.7601 mL	13.8003 mL
20 mM	0.1380 mL	0.6900 mL	1.3800 mL	6.9002 mL
50 mM	0.0552 mL	0.2760 mL	0.5520 mL	2.7601 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc