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SMARCA-BD ligand 1 for Protac
Catalog No. T13848 Copy Product Info
Purity: 99.99%
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SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2.
SMARCA-BD ligand 1 for Protac
Copy Product Info😃Good
Catalog No. T13848
SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2.
Cas No. 1997319-92-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $61 | In Stock | In Stock | |
| 5 mg | $147 | In Stock | In Stock | |
| 10 mg | $239 | In Stock | In Stock | |
| 25 mg | $405 | In Stock | In Stock | |
| 50 mg | $571 | In Stock | In Stock | |
| 100 mg | $778 | In Stock | In Stock | |
| 200 mg | $1,060 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.99%
Appearance:Solid
Color:Yellow
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Product Introduction
SMARCA-BD ligand 1 for Protac AI Summary
SMARCA-BD ligand 1 for Protac exhibits notable interaction and binding affinity with several key proteins, including SMARCA4, SMARCA2, and polybromo-1. It shows a high binding affinity to polybromo-1 with a Kd value of 26.0 nM and significantly increases the melting temperatures of SMARCA4 and SMARCA2 at a concentration of 20 µM, indicating potential bioactivity in modulating these proteins. Furthermore, SMARCA-BD ligand 1 for Protac has inhibitory effects on the bromodomains of SMARCA2, SMARCA4, and PRIM1, with IC50 values of 370.0 nM, 550.0 nM, and 430.0 nM, respectively. These properties suggest its potential as a modulator of chromatin remodeling complexes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2. |
| Molecular Weight | 271.32 |
| Formula | C14H17N5O |
| Cas No. | 1997319-92-2 |
| Smiles | NC1=C(C=C(N=N1)C2=C(O)C=CC=C2)N3CCNCC3 |
| Relative Density. | 1.290 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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