Shopping Cart

Your shopping cart is currently empty

LMT-28

Name: LMT-28
Brand: TargetMol
SKU: T15769
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Hot

Catalog No. T15769Cas No. 1239600-18-0

LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.

LMT-28

Copy Product Info

😃Good

Hot

Purity: 97.55%

Catalog No. T15769Cas No. 1239600-18-0

LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	-	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$212	-	In Stock
50 mg	$333	-	In Stock
100 mg	$487	-	In Stock
1 mL x 10 mM (in DMSO)	$61	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.55%

Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.
In vitro	LMT-28 (1-10000 nM) inhibits IL-6-induced cell proliferation(IC50 = 7.5 μM)[1].
In vivo	In male DBA/1J collagen-induced arthritis mice, LMT-28 (0-0.5 mg/kg) reduces the serum levels of cartilage oligomeric matrix protein, serum amyloid P and anti-CII IgG by 50%, 55%, and 62%[1].

Chemical Properties

Molecular Weight	311.42
Formula	C₁₇H₂₉NO₄
Cas No.	1239600-18-0
Smiles	CCCCCC(=C)[C@@H](O)[C@H](C)C(=O)N1[C@H](COC1=O)C(C)C
Relative Density.	1.065 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (465.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2111 mL	16.0555 mL	32.1110 mL	160.5549 mL
5 mM	0.6422 mL	3.2111 mL	6.4222 mL	32.1110 mL
10 mM	0.3211 mL	1.6055 mL	3.2111 mL	16.0555 mL
20 mM	0.1606 mL	0.8028 mL	1.6055 mL	8.0277 mL
50 mM	0.0642 mL	0.3211 mL	0.6422 mL	3.2111 mL
100 mM	0.0321 mL	0.1606 mL	0.3211 mL	1.6055 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc