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LMT-28

Name: LMT-28
Brand: TargetMol
SKU: T15769
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15769Cas No. 1239600-18-0

LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.

LMT-28

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Purity: 99.88%

Catalog No. T15769Cas No. 1239600-18-0

LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	-	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$212	-	In Stock
50 mg	$333	-	In Stock
100 mg	$487	-	In Stock
1 mL x 10 mM (in DMSO)	$61	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.
In vitro	LMT-28 (1-10000 nM) inhibits IL-6-induced cell proliferation(IC50 = 7.5 μM)[1].
In vivo	In male DBA/1J collagen-induced arthritis mice, LMT-28 (0-0.5 mg/kg) reduces the serum levels of cartilage oligomeric matrix protein, serum amyloid P and anti-CII IgG by 50%, 55%, and 62%[1].

Chemical Properties

Molecular Weight	311.42
Formula	C₁₇H₂₉NO₄
Cas No.	1239600-18-0
Smiles	CCCCCC(=C)[C@@H](O)[C@H](C)C(=O)N1[C@H](COC1=O)C(C)C
Relative Density.	1.065 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (289 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2111 mL	16.0555 mL	32.1110 mL	160.5549 mL
5 mM	0.6422 mL	3.2111 mL	6.4222 mL	32.1110 mL
10 mM	0.3211 mL	1.6055 mL	3.2111 mL	16.0555 mL
20 mM	0.1606 mL	0.8028 mL	1.6055 mL	8.0277 mL
50 mM	0.0642 mL	0.3211 mL	0.6422 mL	3.2111 mL
100 mM	0.0321 mL	0.1606 mL	0.3211 mL	1.6055 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc