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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.

Defactinib
T19961073154-85-4
Defactinib (VS-6063) is a second-generation inhibitor of FAK that inhibits FAK phosphorylation at the Tyr397 site. Defactinib has potential antitumor activity.
  • $31
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PND-1186
T19501061353-68-1
PND-1186 (VS-4718) is a specific and reversible FAK inhibitor with an IC50 of 1.5 nM.
  • $30
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ifebemtinib
T641671227948-82-4In house
Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer.
  • $165
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OXA-11
T282771257994-15-2
OXA-11 (FAK-IN-16) is an orally active, selective focal adhesion kinase (FAK) inhibitor with antitumor activity. It inhibits FAK phosphorylation at tyrosine 397 in a dose-dependent manner and suppresses TOV21G tumor growth. It is used in cancer research.
  • $1,590
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Ifebemtinib FA
T64167L In house
Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.
  • $163
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Batatasin III
TN143356684-87-8
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination
  • $107
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Corosolic acid
T33914547-24-4
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by inducing apoptosis and promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin.
  • $39
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PF-562271
T2465717907-75-0
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
  • $54
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NAMI-A
T16266201653-76-1
NAMI-A, a ruthenium-based compound, selectively targets tumor metastasis by inhibiting cancer cell adhesion and migration.
  • $47
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FAK activator 1
T776651211825-25-0In house
ZINC40099027 is a specific adhesion plaque kinase (FAK) activator that promotes gastric mucosal repair in persistent aspirin-associated gastric injury through activation of adhesion plaque kinase, activates human adhesion plaque kinase by accelerating the enzyme activity of the structural domain of FAK kinase, activates cytosolic FAK, and promotes intestinal epithelial wound closure.
  • $93 TargetMol
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Fangchinoline
T3122436-77-1
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
  • $43
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Y15
T71194506-66-5
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
  • $43
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PF-562271 hydrochloride
T21768939791-41-0
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
  • $71
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SU6656
T6997330161-87-0
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
  • $34
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PF-573228
T2001869288-64-2
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
  • $45
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Masitinib mesylate
T85441048007-93-7
Masitinib mesylate (AB-1010 mesylate) is a selective, orally bioavailable c-Kit inhibitor with an IC50 of 200 nM for human recombinant c-Kit, and IC50 values of 540 800 nM and 510 nM for PDGFRα β and LynB, respectively.
  • $30
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CEP-37440
T26551391712-60-9
CEP-37440 is an effective and specific Dual FAK ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
  • $31
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AMP-945
T95761393653-34-3
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
  • $98
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GSK2256098
T22811224887-10-8
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
  • $39
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Chloropyramine hydrochloride
T02636170-42-9
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.
  • $33
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BMS-536924
T6419468740-43-4
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R IR inhibitor with IC50 of 100 nM 73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1 2.
  • $33
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Nitidine chloride
T5S076113063-04-2
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.
  • $32
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ALK inhibitor 2
T3041761438-38-4
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
  • $118
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Masitinib
T2609790299-79-5
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.
  • $31
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