Shopping Cart

Your shopping cart is currently empty

GNE-490

Name: GNE-490
Brand: TargetMol
SKU: T22339
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22339Cas No. 1033739-92-2

GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).

GNE-490

🥰Excellent

Purity: 99.77%

Catalog No. T22339Cas No. 1033739-92-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$77	-	In Stock
2 mg	$117	-	In Stock
5 mg	$198	-	In Stock
10 mg	$338	-	In Stock
25 mg	$535	-	In Stock
50 mg	$738	-	In Stock
100 mg	$980	-	In Stock
200 mg	$1,350	-	In Stock
1 mL x 10 mM (in DMSO)	$215	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.77%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).
Targets&IC50	mTOR:750 nM, PI3Kδ:5.2 nM, PI3Kγ:15 nM, PI3Kβ:25 nM, PI3Kα:3.5 nM

Chemical Properties

Molecular Weight	386.47
Formula	C₁₈H₂₂N₆O₂S
Cas No.	1033739-92-2
Smiles	Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (129.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5875 mL	12.9376 mL	25.8752 mL	129.3761 mL
5 mM	0.5175 mL	2.5875 mL	5.1750 mL	25.8752 mL
10 mM	0.2588 mL	1.2938 mL	2.5875 mL	12.9376 mL
20 mM	0.1294 mL	0.6469 mL	1.2938 mL	6.4688 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL	2.5875 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2938 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc