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Amifostine thiol

🥰Excellent
Catalog No. T37538Cas No. 31098-42-7
Alias WR-1065

Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.

Amifostine thiol
Other Forms of Amifostine thiol:
Amifostine thiol dihydrochlorideTQ013314653-77-1
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Amifostine thiol

🥰Excellent
Catalog No. T37538Alias WR-1065Cas No. 31098-42-7
Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.
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2 mg$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:≥95.0%
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Product Introduction

Bioactivity
Description
Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.
In vitro
4 mM Amifostine thiol exhibits a protective effect against the genome instability induced by 30 minutes of X-ray irradiation, and also protects RKO36 cells from chromosomal damage and death caused by ionizing radiation[1].
SynonymsWR-1065
Chemical Properties
Molecular Weight134.24
FormulaC5H14N2S
Cas No.31098-42-7
SmilesNCCCNCCS
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 80 mg/mL (595.95 mM), Sonication is recommended.
DMSO: 200 mg/mL (1489.87 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM7.4493 mL37.2467 mL74.4934 mL372.4672 mL
5 mM1.4899 mL7.4493 mL14.8987 mL74.4934 mL
10 mM0.7449 mL3.7247 mL7.4493 mL37.2467 mL
20 mM0.3725 mL1.8623 mL3.7247 mL18.6234 mL
50 mM0.1490 mL0.7449 mL1.4899 mL7.4493 mL
100 mM0.0745 mL0.3725 mL0.7449 mL3.7247 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

MDM-2/p53Amifostine thiol
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