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Amifostine thiol

Name: Amifostine thiol
Brand: TargetMol
SKU: T37538
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37538Cas No. 31098-42-7

Alias WR-1065

Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.

Amifostine thiol

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Catalog No. T37538Alias WR-1065Cas No. 31098-42-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	Preferential	-	In Stock
10 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥95.0%

Appearance:Solid

Color:White

Resource Download

COA HNMR MS

Product Introduction

Bioactivity

Description	Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.
In vitro	4 mM Amifostine thiol exhibits a protective effect against the genome instability induced by 30 minutes of X-ray irradiation, and also protects RKO36 cells from chromosomal damage and death caused by ionizing radiation[1].
Synonyms	WR-1065

Chemical Properties

Molecular Weight	134.24
Formula	C₅H₁₄N₂S
Cas No.	31098-42-7
Smiles	NCCCNCCS

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (595.95 mM), Sonication is recommended.

DMSO: 200 mg/mL (1489.87 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.4493 mL	37.2467 mL	74.4934 mL	372.4672 mL
5 mM	1.4899 mL	7.4493 mL	14.8987 mL	74.4934 mL
10 mM	0.7449 mL	3.7247 mL	7.4493 mL	37.2467 mL
20 mM	0.3725 mL	1.8623 mL	3.7247 mL	18.6234 mL
50 mM	0.1490 mL	0.7449 mL	1.4899 mL	7.4493 mL
100 mM	0.0745 mL	0.3725 mL	0.7449 mL	3.7247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc