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Glycopyrrolate

Name: Glycopyrrolate
Brand: TargetMol
SKU: T2387
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2387Cas No. 596-51-0

Alias Robinul, Glycopyrronium bromide, Glycopyrrolate bromide, Gastrodyn

Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

Glycopyrrolate

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Purity: 99.64%

Catalog No. T2387Alias Robinul, Glycopyrronium bromide, Glycopyrrolate bromide, GastrodynCas No. 596-51-0

Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$53	In Stock	In Stock
50 mg	$73	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$238	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.64%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
In vitro	Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6?nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors[1].
Synonyms	Robinul, Glycopyrronium bromide, Glycopyrrolate bromide, Gastrodyn

Chemical Properties

Molecular Weight	398.33
Formula	C₁₉H₂₈BrNO₃
Cas No.	596-51-0
Smiles	[Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C1CCCC1)C1=CC=CC=C1
Relative Density.	1.3222 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (125.52 mM), Sonication is recommended.

H2O: 72 mg/mL (180.75 mM), Sonication is recommended.

Ethanol: 55 mg/mL (138.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5105 mL	12.5524 mL	25.1048 mL	125.5241 mL
5 mM	0.5021 mL	2.5105 mL	5.0210 mL	25.1048 mL
10 mM	0.2510 mL	1.2552 mL	2.5105 mL	12.5524 mL
20 mM	0.1255 mL	0.6276 mL	1.2552 mL	6.2762 mL
50 mM	0.0502 mL	0.2510 mL	0.5021 mL	2.5105 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2552 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc