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HPMC (Type II, Viscosity:100000mPa.s)
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Catalog No. T19368Cas No. 9004-65-3
Alias Hypromellose, HPMC, Celacol HPM 5000, (Hydroxypropyl)methyl cellulose
HPMC (Type II,Viscosity:100000mPa.s) is a water-soluble hydrophilic, non-ionic cellulose ether.
HPMC (Type II, Viscosity:100000mPa.s)
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Catalog No. T19368Alias Hypromellose, HPMC, Celacol HPM 5000, (Hydroxypropyl)methyl celluloseCas No. 9004-65-3
HPMC (Type II,Viscosity:100000mPa.s) is a water-soluble hydrophilic, non-ionic cellulose ether.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 g | $39 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | HPMC (Type II,Viscosity:100000mPa.s) is a water-soluble hydrophilic, non-ionic cellulose ether. |
| In vitro | Hypromellose (hydroxypropylmethylcellulose) is a long-established component of sustained-release pharmaceutical formulations. In matrix tablets, this polymer rapidly absorbs water, forming a viscous gel barrier that encapsulates the tablet. The modulation of drug release rates by hypromellose is governed by several factors, including the water diffusion rate into the polymer, the kinetics of hypromellose hydration and subsequent gelation, the viscosity of the gel produced, and the erosion rate of the gel layer [2]. This mechanism enables hypromellose to facilitate a controlled drug release, extending the drug's therapeutic efficacy [1]. |
| In vivo | Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye, significantly reducing symptoms as indicated by fluorescein and rose bengal staining tests [3]. Hypromellose also improves blood glucose metabolism and suppresses oxidative stress in mice on a high-fat diet, likely through the regulation of hepatic glucose-regulating enzyme activities and activation of hepatic and erythrocyte antioxidant enzymes [4]. |
| Synonyms | Hypromellose, HPMC, Celacol HPM 5000, (Hydroxypropyl)methyl cellulose |
| Molecular Weight | 1261.44 |
| Formula | C56H108O30 |
| Cas No. | 9004-65-3 |
| Smiles | CC(O)COC[C@H]1O[C@@H](O[C@H]2[C@H](OCC(O)C)[C@@H](OCC(O)C)[C@H](OCC(O)C)O[C@@H]2COCC(O)C)[C@H](OCC(O)C)[C@@H](OCC(O)C)[C@@H]1OCC(O)C.COC[C@H]3O[C@@H](O[C@H]4[C@H](OC)[C@@H](OC)[C@H](OC)O[C@@H]4COC)[C@H](OC)[C@@H](OC)[C@@H]3OC |
| Relative Density. | 1.39 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 12.62 mg/mL (10 mM), Sonication is recommended.  H2O: 12.65 mg/mL (10.03 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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