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Autogramin-2

🥰Excellent
Catalog No. T9013Cas No. 2375541-45-8
Alias tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)

Autogramin-2

Autogramin-2

🥰Excellent
Purity: 96.25%
Catalog No. T9013Alias tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylateCas No. 2375541-45-8
Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$38In StockIn Stock
10 mg$59In StockIn Stock
25 mg$113In StockIn Stock
50 mg$178In StockIn Stock
100 mg$278In StockIn Stock
200 mg$392-In Stock
1 mL x 10 mM (in DMSO)$43In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.25%
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Product Introduction

Bioactivity
Description
Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50:0.14 μM)
Targets&IC50
Autophagy:0.27 μM
Synonymstert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Chemical Properties
Molecular Weight417.52
FormulaC21H27N3O4S
Cas No.2375541-45-8
SmilesCC(C)Oc1ccc(cc1)C(=O)Nc1nc2CCN(Cc2s1)C(=O)OC(C)(C)C
Relative Density.1.252 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 83.33 mg/mL (199.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3951 mL11.9755 mL23.9509 mL119.7547 mL
5 mM0.4790 mL2.3951 mL4.7902 mL23.9509 mL
10 mM0.2395 mL1.1975 mL2.3951 mL11.9755 mL
20 mM0.1198 mL0.5988 mL1.1975 mL5.9877 mL
50 mM0.0479 mL0.2395 mL0.4790 mL2.3951 mL
100 mM0.0240 mL0.1198 mL0.2395 mL1.1975 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

InhibitorinhibitautophagyAutophagyAutogramin-2Autogramin2Autogramin 2
Related Tags: buy Autogramin-2 | purchase Autogramin-2 | Autogramin-2 cost | order Autogramin-2 | Autogramin-2 chemical structure | Autogramin-2 formula | Autogramin-2 molecular weight
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