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Calpain Inhibitor XII (Alias: Z-L-Nva-CONH-CH2-2-Py)

Name: Calpain Inhibitor XII
Brand: TargetMol
SKU: T21949
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T21949 Copy Product Info

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Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture.

Calpain Inhibitor XII

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Catalog No. T21949

Alias Z-L-Nva-CONH-CH2-2-Py

Cas No. 181769-57-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$142	-	In Stock
5 mg	$391	-	In Stock
10 mg	$573	-	In Stock
25 mg	$883	-	In Stock
50 mg	$1,190	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture.
Targets&IC50	SARS-CoV-2 (primary CPE assay):0.49 µM (EC50), SARS-CoV-2 (secondary VYR assay):0.78 µM (EC50)
In vitro	Four compounds boceprevir, calpain inhibitors II, Calpain Inhibitor XII, and GC-376 were chosen for the antiviral assay with infectious SARS-CoV-2. The most potent compound was Calpain Inhibitor XII, which showed an EC50 = 0.49 µM in the primary CPE assay and an EC50 = 0.78 µM in the secondary VYR assay. [1]
Synonyms	Z-L-Nva-CONH-CH2-2-Py

Chemical Properties

Molecular Weight	482.57
Formula	C₂₆H₃₄N₄O₅
Cas No.	181769-57-3
Smiles	O=C(OCC=1C=CC=CC1)NC(C(=O)NC(C(=O)C(=O)NCC2=NC=CC=C2)CCC)CC(C)C
Relative Density.	1.167 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (20.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0722 mL	10.3612 mL	20.7224 mL	103.6119 mL
5 mM	0.4144 mL	2.0722 mL	4.1445 mL	20.7224 mL
10 mM	0.2072 mL	1.0361 mL	2.0722 mL	10.3612 mL
20 mM	0.1036 mL	0.5181 mL	1.0361 mL	5.1806 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc