store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium salt is used in the study of type 2 diabetes and obesity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 247.00 | |
5 mg | In stock | $ 622.00 | |
10 mg | In stock | $ 997.00 | |
25 mg | In stock | $ 1,470.00 | |
50 mg | In stock | $ 1,990.00 | |
100 mg | In stock | $ 2,690.00 |
Description | Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium salt is used in the study of type 2 diabetes and obesity. |
Targets&IC50 | GIPR:0.191 nM (EC50, mouse), GIPR:0.0643 nM (EC50, human), GLP1R:0.794 nM (EC50, mouse), GLP1R:0.775 nM (EC50, human), GCGR:5.79 nM (EC50, human), GCGR:2.32 nM (EC50, mouse) |
In vitro |
Retatrutide sodium salt exhibits activity against human GCGR, GIPR, and GLP-1R, with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively[1]. In mouse models, Retatrutide sodium salt demonstrates activity against GCGR, GIPR, and GLP-1R, with EC50 values of 2.32, 0.191, and 0.794 nM, respectively[1]. The binding affinities of Retatrutide sodium salt for human GCGR, GIPR, and GLP-1R are characterized by Ki values of 5.6, 0.057, and 7.2 nM, respectively[1]. For mouse GCGR, GIPR, and GLP-1R, Retatrutide sodium salt exhibits binding affinities with Ki values of 73, 2.8, and 1.3 nM, respectively[1]. |
In vivo |
Retatrutide sodium salt, administered via subcutaneous injection at a single dose of 0.47 mg/kg, engages with the glucagon receptor (GCGR) in vivo and improves glucose tolerance in an intraperitoneal glucose tolerance test (ipGTT) through activation of GIP or GLP-1 receptors[1]. With subcutaneous injections at a dose of 10 mL/kg every 3 days for a cycle of 21 days, Retatrutide sodium salt induces significant weight loss and increased energy expenditure through activation of the glucagon-like peptide-1 (GLP-1) receptor[1]. Retatrutide sodium salt demonstrates safety and tolerability in these studies[1]. |
Synonyms | Retatrutide sodium salt(2381089-83-2 free base), LY3437943 sodium salt |
Molecular Weight | N/A |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Retatrutide sodium salt GPCR/G Protein Glucagon Receptor Retatrutide sodium salt(2381089-83-2 free base) Flagelin22sodiumsalt(304642919freebase) LY3437943 sodium salt inhibitor inhibit