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MC2184

Name: MC2184
Brand: TargetMol
SKU: T50080
Rating: 4.5 (1 reviews)

Catalog No. T50080 Copy Product Info

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MC2184 is the inhibitor of human recombinant SIRT1.

MC2184

Copy Product Info

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Catalog No. T50080

MC2184 is the inhibitor of human recombinant SIRT1.

Cas No. 74901-20-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$77	Inquiry	Inquiry
5 mg	$179	Inquiry	Inquiry
10 mg	$268	Inquiry	Inquiry
25 mg	$442	Inquiry	Inquiry
50 mg	$592	Inquiry	Inquiry
100 mg	$828	Inquiry	Inquiry
200 mg	$1,090	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

MC2184 AI Summary

MC2184 shows bioactivity as an inhibitor of both human recombinant SIRT1 and SIRT2 enzymes, with an IC50 value of 5300.0 nM for SIRT1 inhibition and 243600.0 nM for SIRT2 inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

MC2184 is the inhibitor of human recombinant SIRT1.

Chemical Properties

Molecular Weight	214.18
Formula	C₁₁H₆N₂O₃
Cas No.	74901-20-5
Smiles	O=C1C=2C(OC=3C(C2)=CC=CC3)=NC(=O)N1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (46.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6690 mL	23.3449 mL	46.6897 mL	233.4485 mL
5 mM	0.9338 mL	4.6690 mL	9.3379 mL	46.6897 mL
10 mM	0.4669 mL	2.3345 mL	4.6690 mL	23.3449 mL
20 mM	0.2334 mL	1.1672 mL	2.3345 mL	11.6724 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc