Alpha-Synuclein Protein,Human,Recombinant (H50Q)

Name: Alpha-Synuclein Protein,Human,Recombinant (H50Q)
Brand: TargetMol
SKU: TMPY-06318
Rating: 4.5 (1 reviews)

(Synonyms: synuclein, α (non A4 component of amyloid precursor), synuclein, alpha (non A4 component of amyloid precursor), PD1, PARK4, PARK1, NACP, Human α-Synuclein Protein (H50Q)) Copy Product Info

Synonyms: synuclein, α (non A4 component of amyloid precursor), synuclein, alpha (non A4 component of amyloid precursor), PD1, PARK4, PARK1, NACP, Human α-Synuclein Protein (H50Q)

Catalog No. TMPY-06318 Copy Product Info

Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$38	7-10 days	7-10 days
10 µg	$58	7-10 days	7-10 days
20 µg	$93	7-10 days	7-10 days
50 µg	$172	7-10 days	7-10 days
100 µg	$343	7-10 days	7-10 days
200 µg	$520	7-10 days	7-10 days
500 µg	$1,090	7-10 days	7-10 days
1 mg	$2,230	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P37840-1
Construction	A DNA sequence encoding the human SNCA (P37840-1) (H50Q, Met1-Ala140) was expressed. Predicted N terminal: Met 1
Protein Purity	≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS 2 mM TCEP, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	synuclein, α (non A4 component of amyloid precursor), synuclein, alpha (non A4 component of amyloid precursor), PD1, PARK4, PARK1, NACP, Human α-Synuclein Protein (H50Q)
Research Background	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.

Chemical Properties

Molecular Weight

14.45 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.