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Myosin V-IN-1

Name: Myosin V-IN-1
Brand: TargetMol
SKU: T72060
Price: 330 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72060Cas No. 1259177-59-7

Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.

Myosin V-IN-1

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Purity: 98.89%

Catalog No. T72060Cas No. 1259177-59-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$330	In Stock	In Stock
5 mg	$698	In Stock	In Stock
10 mg	$993	In Stock	In Stock
25 mg	$1,470	In Stock	In Stock
50 mg	$1,990	In Stock	In Stock
100 mg	$2,680	-	In Stock
1 mL x 10 mM (in DMSO)	$713	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.89%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
Targets&IC50	Myosin V:6 μM(Ki)
In vitro	Myosin V-IN-1 (compound 8) exhibits a dose-dependent decrease in the rate of actin-activated ATP hydrolysis by single-headed myosin V.[1]

Chemical Properties

Molecular Weight	538.62
Formula	C₂₉H₂₆N₆O₃S
Cas No.	1259177-59-7
Smiles	N(C=1N=C2C(C(=NN2)C3=CC=C(C=C3)N4CCOCC4)=CN1)C5=CC(CSC6=CC(C(O)=O)=CC=C6)=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (167.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8566 mL	9.2830 mL	18.5660 mL	92.8298 mL
5 mM	0.3713 mL	1.8566 mL	3.7132 mL	18.5660 mL
10 mM	0.1857 mL	0.9283 mL	1.8566 mL	9.2830 mL
20 mM	0.0928 mL	0.4641 mL	0.9283 mL	4.6415 mL
50 mM	0.0371 mL	0.1857 mL	0.3713 mL	1.8566 mL
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc