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Myosin V-IN-1

🥰Excellent
Catalog No. T72060Cas No. 1259177-59-7

Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.

Myosin V-IN-1

Myosin V-IN-1

🥰Excellent
Purity: 98.64%
Catalog No. T72060Cas No. 1259177-59-7
Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$330In StockIn Stock
5 mg$698In StockIn Stock
10 mg$993In StockIn Stock
25 mg$1,470In StockIn Stock
50 mg$1,990In StockIn Stock
100 mg$2,680-In Stock
1 mL x 10 mM (in DMSO)$713In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.64%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
Targets&IC50
Myosin V:6 μM(Ki)
In vitro
Myosin V-IN-1 (compound 8) exhibits a dose-dependent decrease in the rate of actin-activated ATP hydrolysis by single-headed myosin V.[1]
Chemical Properties
Molecular Weight538.62
FormulaC29H26N6O3S
Cas No.1259177-59-7
SmilesN(C=1N=C2C(C(=NN2)C3=CC=C(C=C3)N4CCOCC4)=CN1)C5=CC(CSC6=CC(C(O)=O)=CC=C6)=CC=C5
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90.0 mg/mL (167.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8566 mL9.2830 mL18.5660 mL92.8298 mL
5 mM0.3713 mL1.8566 mL3.7132 mL18.5660 mL
10 mM0.1857 mL0.9283 mL1.8566 mL9.2830 mL
20 mM0.0928 mL0.4641 mL0.9283 mL4.6415 mL
50 mM0.0371 mL0.1857 mL0.3713 mL1.8566 mL
100 mM0.0186 mL0.0928 mL0.1857 mL0.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Myosin
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