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TREM2-IN-1

🥰Excellent
Catalog No. T87562Cas No. 2000236-36-0

TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.

TREM2-IN-1

TREM2-IN-1

🥰Excellent
Purity: 98.56%
Catalog No. T87562Cas No. 2000236-36-0
TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.
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1 mg$799-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.56%
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Product Introduction

Bioactivity
Description
TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.
In vitro
TREM2-IN-1 (0.8 μM, 72 h) inhibited the early phase of DNA synthesis (G1 phase) in HCT-116 cells and had a strong pro-apoptotic ability.
Trem2-in-1 (1 μM, 24 h) significantly inhibited the expression of TREM2 IN THP-1-derived macrophages. [1]
In vivo
TREM2-IN-1 (1.5 mg Pt per kg, treated, a single dose, lasting 15 days) was effective in inhibiting tumor growth in a C57BL/6 mouse model with MC38 mouse colon cancer and was less toxic overall. [1]
Chemical Properties
Molecular Weight1164.12
FormulaC46H68N2O20Pt
Cas No.2000236-36-0
Smiles[O-](C(CCC(O[C@@H]1O[C@]2([C@]34[C@]([C@H]1C)(CC[C@@H](C)[C@@]3(CC[C@](C)(O2)OO4)[H])[H])[H])=O)=O)[Pt+4]56([O-]C(CCC(O[C@@H]7O[C@]8([C@]9%10[C@]([C@H]7C)(CC[C@@H](C)[C@@]9(CC[C@](C)(O8)OO%10)[H])[H])[H])=O)=O)([NH2]C%11C([NH2]5)CCCC%11)[O-]C(=O)C(=O)[O-]6
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (68.72 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (2.83 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8590 mL4.2951 mL8.5902 mL42.9509 mL
5 mM0.1718 mL0.8590 mL1.7180 mL8.5902 mL
10 mM0.0859 mL0.4295 mL0.8590 mL4.2951 mL
20 mM0.0430 mL0.2148 mL0.4295 mL2.1475 mL
50 mM0.0172 mL0.0859 mL0.1718 mL0.8590 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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