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NS-1619

Name: NS-1619
Brand: TargetMol
SKU: T3102
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3102Cas No. 153587-01-0

NS1619 have cardio-protective effects after ischemia-reperfusion injury.

NS-1619

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Purity: 98%

Catalog No. T3102Cas No. 153587-01-0

NS1619 have cardio-protective effects after ischemia-reperfusion injury.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$147	In Stock	In Stock
50 mg	$222	In Stock	In Stock
100 mg	$333	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

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Product Introduction

NS-1619 AI Summary

NS-1619 demonstrates a wide range of bioactivities across various biological systems and assays. It acts as an activator of maxi-K (BK) channels expressed in Xenopus laevis oocytes and CHO-K1 cells, showing significant increases in channel opening at concentrations of 20 uM and 30 uM, respectively. This includes a notable 325.2% relative increase in ionic current in CHO-K1 cells and a 116.0% increase in outward current in Xenopus laevis oocytes. The compound also induces BK channel-mediated vasorelaxation in KCl-induced contraction in Wistar rat aorta, with an Emax of up to 94.0% and IC50 values ranging from 4365.16 nM to 5888.44 nM. Additionally, NS-1619 exhibits protective effects against Bacillus anthracis lethal toxin in mouse RAW264.7 cells, increasing cell viability by 2.8-fold compared to controls. It has antiplasmodial activity against Plasmodium falciparum strains and demonstrates binding affinity to the Hsp90alpha N-terminal ATPase domain with an IC50 of 3320 nM. The compound also exhibits high plasma protein binding activity in mouse, human, and rat plasma samples, with PPB values exceeding 99.79%. Collectively, these findings highlight NS-1619's potential therapeutic applications in various disease pathways and cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NS1619 have cardio-protective effects after ischemia-reperfusion injury.
Targets&IC50	BKCa channel:32 microM(ec50)

Chemical Properties

Molecular Weight	362.23
Formula	C₁₅H₈F₆N₂O₂
Cas No.	153587-01-0
Smiles	Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Relative Density.	1.563 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (138.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7607 mL	13.8034 mL	27.6068 mL	138.0338 mL
5 mM	0.5521 mL	2.7607 mL	5.5214 mL	27.6068 mL
10 mM	0.2761 mL	1.3803 mL	2.7607 mL	13.8034 mL
20 mM	0.1380 mL	0.6902 mL	1.3803 mL	6.9017 mL
50 mM	0.0552 mL	0.2761 mL	0.5521 mL	2.7607 mL
100 mM	0.0276 mL	0.1380 mL	0.2761 mL	1.3803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc