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Tiopronin

Name: Tiopronin
Brand: TargetMol
SKU: T1630
Rating: 4.5 (1 reviews)

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Catalog No. T1630Cas No. 1953-02-2

Alias Thiopronine, Captimer, Acadione

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

Tiopronin

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Purity: 98%

Catalog No. T1630Alias Thiopronine, Captimer, AcadioneCas No. 1953-02-2

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$39	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

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COA

Product Introduction

Bioactivity

Description	Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.
In vitro	Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. [1] Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. [2] Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. [3] Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices. [4]
In vivo	Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level. [5]
Synonyms	Thiopronine, Captimer, Acadione

Chemical Properties

Molecular Weight	163.19
Formula	C₅H₉NO₃S
Cas No.	1953-02-2
Smiles	C(NCC(O)=O)(C(C)S)=O
Relative Density.	1.249 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (183.83 mM), Sonication is recommended.

H2O: 29 mg/mL (177.71 mM), Sonication is recommended.

DMSO: 70 mg/mL (428.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1278 mL	30.6391 mL	61.2783 mL	306.3913 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL	61.2783 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL	30.6391 mL
20 mM	0.3064 mL	1.5320 mL	3.0639 mL	15.3196 mL
50 mM	0.1226 mL	0.6128 mL	1.2256 mL	6.1278 mL
100 mM	0.0613 mL	0.3064 mL	0.6128 mL	3.0639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc