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W23-1006

Catalog No. T205034 Copy Product Info
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W23-1006 is a novel, selective, and cell-active covalent inhibitor of ALKBH5 (an m6A RNA demethylase). It functions by binding to the C200 residue of ALKBH5 with an IC50 value of 3.848 μM. W23-1006 demonstrates superior selectivity, being approximately 30-fold and 8-fold more potent against ALKBH5 than against FTO and ALKBH3, respectively. By inhibiting ALKBH5 and increasing global m6A abundance, W23-1006 effectively suppresses proliferation, migration, and colonization in triple-negative breast cancer (TNBC) cells.

W23-1006

Copy Product Info
🥰Excellent
Catalog No. T205034

W23-1006 is a novel, selective, and cell-active covalent inhibitor of ALKBH5 (an m6A RNA demethylase). It functions by binding to the C200 residue of ALKBH5 with an IC50 value of 3.848 μM. W23-1006 demonstrates superior selectivity, being approximately 30-fold and 8-fold more potent against ALKBH5 than against FTO and ALKBH3, respectively. By inhibiting ALKBH5 and increasing global m6A abundance, W23-1006 effectively suppresses proliferation, migration, and colonization in triple-negative breast cancer (TNBC) cells.

W23-1006
Cas No. 3035498-92-8
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$83-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:Brown
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Product Introduction

Bioactivity
Description
W23-1006 is a novel, selective, and cell-active covalent inhibitor of ALKBH5 (an m6A RNA demethylase). It functions by binding to the C200 residue of ALKBH5 with an IC50 value of 3.848 μM. W23-1006 demonstrates superior selectivity, being approximately 30-fold and 8-fold more potent against ALKBH5 than against FTO and ALKBH3, respectively. By inhibiting ALKBH5 and increasing global m6A abundance, W23-1006 effectively suppresses proliferation, migration, and colonization in triple-negative breast cancer (TNBC) cells.
In vitro
In TNBC cells, W23-1006 (5 μM) elevates global m6A modification and dose-dependently (3.16–31.6 μM) inhibits cell viability. It also suppresses migration and colonization by inducing G2/M arrest and apoptosis [1].
In vivo
W23-1006 (25 mg/kg, i.p.) exhibits potent antitumor efficacy in mouse xenograft models. It is rapidly absorbed (Tmax = 15 min) with a half-life of 0.5–1 h. No overt toxicity is observed up to 250 mg/kg, indicating a favorable safety profile [1].
Chemical Properties
Molecular Weight418.2
FormulaC17H12BrN3O5
Cas No.3035498-92-8
SmilesO=C1NN(C2=CC=C(C=C2)OC)C(C1=CC3=CC(Br)=CC([N+]([O-])=O)=C3)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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