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ApoptosisDAPK
DAPK (Death-associated protein kinase) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to disease. The DAPk family has been linked to several cell death-related signaling pathways, and functions other than cell death have also been proposed.
3MB-PP1
T21678956025-83-5In house
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.
- $48
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TNIK-IN-3
T95562754265-25-1In house
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 μM), Flt1 (IC50 = 0.191 μM), and DRAK1 (IC50 = 0.411 μM). This compound holds potential for carrying out research on colorectal cancer (CRC) [1].
- $108
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HS94
T777771892594-93-2
HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
- $34
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BRD7389
Cited
T14779376382-11-5
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
- $29
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CitedHS38
T275541030203-81-6
HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
- $47
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TC-DAPK 6
T17004315694-89-4
TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.
- $32
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DAPK Substrate Peptide acetate
TP2205L
DAPK Substrate Peptide acetate is a death-associated protein kinase (DAPK, Km = 9 μM) peptide substrate.
- $155
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DAPK-IN-2
T77611304000-05-3
DAPK-IN-2 (WAY-380496) is a DAPK inhibitor. DAPK-IN-2 has potential anticancer activity, regulates autophagy and can be used to study cerebral infarction and ischemic diseases.
- $39
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HS148
T777761892595-16-2
HS148 is a selective inhibitor of DAPK3 (death-associated protein kinase 3), with a Ki value of 119 nM. Inhibition of DAPK3 by HS148 has been shown to reduce the progression of gastric cancer by activating the ULK1-dependent pathway, which is implicated in cellular autophagy and tumor suppression mechanisms.
- $44
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DAPK1-IN-1
T2007171429522-04-2
DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.
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DAPK Substrate Peptide TFA
T75923
DAPK Substrate Peptide TFA is a synthetic peptide used as a substrate for the enzyme death-associated protein kinase (DAPK), with a Michaelis constant (Km) of 9 μM [1].
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DRAK2-IN-1
T11094871837-60-4
Drak2-in-1, a potent, selective and ATP-competitive DRAK2 inhibitor, has an IC50 and KIvalue of 3 nM and 0.26 nM, respectively.Drak2-in-1 also had an effect on DRAK1 (IC50=51 nM).
- $766
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STK17A/B-IN-1
T887013002038-21-0
STK17A/B-IN-1 (compound 9) is an orally active, potent, and selective inhibitor of STK17A/B, demonstrating an IC50 of 23 nM for STK17A. This compound is utilized in tumor research.
- $1,520
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DAPK Substrate Peptide
TP2205386769-53-5
DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) [Km = 9 μM].
- $294
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STK17A/B-IN-1 hydrochloride
T201324
STK17A B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.
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TAT-GluN2BCTM
T802101587742-50-4
TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, protecting neurons against oxidative stress and NMDAR-mediated excitotoxicity, making it valuable for neuroprotection research studies [1].
- Inquiry Price
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DRAK1/2-IN-1
T729571629227-34-4
DRAK1 2-IN-1 is a potent inhibitor targeting both DRAK1 and DRAK2, displaying dissociation constants (Kd) of 1 µM and 6 µM, respectively.
- $1,520
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hs56
T68341922050-57-5
HS56 is an ATP-competitive dual Pim DAPK3 inhibitor, displaying K_i values of 0.26 μM for DAPK3, 0.208 μM for Pim-3, 2.94 μM for Pim-1, and >100 μM for Pim-2. This compound effectively inhibits LC20 phosphorylation and smooth muscle contraction, and reduces blood pressure in spontaneously hypertensive mice, making it a valuable tool for hypertension research [HS-56].
- $1,520
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CK156
T618432910938-59-7
CK156 is a potent inhibitor of death-associated protein kinase (DAPK), demonstrating high selectivity. In the DRAK1 NanoBRET assay, CK156 exhibits IC50 values of 182 nM, 34 μM, and 39 μM for DRAK1, CK2a1, and CK2a2, respectively. This compound is valuable for studying autoimmune and inflammatory diseases [1].
- $1,520
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