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PD-166285
Catalog No. T213116 Copy Product Info
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PD-166285 is an inhibitor of PKMYT1 with an IC50 value of 17 nM. It exhibits potent antiproliferative effects on CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD-166285 can induce apoptosis and cause CCNE1-amplified HCC1569 cells to arrest at the G1/S phase of the cell cycle. This compound is applicable for research on PKMYT1-targeted CCNE1-amplified cancers.
PD-166285
Copy Product Info🥰Excellent
Catalog No. T213116
PD-166285 is an inhibitor of PKMYT1 with an IC50 value of 17 nM. It exhibits potent antiproliferative effects on CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD-166285 can induce apoptosis and cause CCNE1-amplified HCC1569 cells to arrest at the G1/S phase of the cell cycle. This compound is applicable for research on PKMYT1-targeted CCNE1-amplified cancers.
PD-166285
Cas No. 717094-37-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | PD-166285 is an inhibitor of PKMYT1 with an IC50 value of 17 nM. It exhibits potent antiproliferative effects on CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD-166285 can induce apoptosis and cause CCNE1-amplified HCC1569 cells to arrest at the G1/S phase of the cell cycle. This compound is applicable for research on PKMYT1-targeted CCNE1-amplified cancers. |
| Targets&IC50 | PKMYT1:17 nM |
| In vitro | PD166285 demonstrates significant antiproliferative effects in CCNE1-amplified OVCAR3 cells (IC 50 = 0.14 μM) and HCC1569 cells (IC 50 = 0.21 μM) when applied at concentrations ranging from 0.062 to 1 μM over 5 days. It also inhibits colony formation in a dose-dependent manner in the same cells over 14 days, with an EC 50 of 0.06 μM for OVCAR3 cells and 0.16 μM for HCC1569 cells. Additionally, PD166285 induces apoptosis and causes arrest of CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle when used at concentrations of 0.125 to 1 μM over 5 days. |
| Molecular Weight | 484.38 |
| Formula | C24H23Cl2N5O2 |
| Cas No. | 717094-37-6 |
| Smiles | O=C1C(=CC=2C=NC(=NC2N1C)NC3=CC=C(OCCN(C)C)C=C3)C4=C(Cl)C=CC=C4Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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