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Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody
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Catalog No. TMAC-01439
Alias p-FANCD2 (Ser222), p-FANCD2 (S222), FANCD2 (p-Ser222), FANCD2 (p-S222)
Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FANCD2 (Ser222). Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody can be used in WB.
Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody
Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody
😃Good
Catalog No. TMAC-01439Alias p-FANCD2 (Ser222), p-FANCD2 (S222), FANCD2 (p-Ser222), FANCD2 (p-S222)
Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FANCD2 (Ser222). Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $217 | 7-10 days | 7-10 days | |
| 100 μL | $317 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FANCD2 (Ser222). Anti-Phospho-FANCD2 (Ser222) Polyclonal Antibody can be used in WB. |
| Synonyms | p-FANCD2 (Ser222), p-FANCD2 (S222), FANCD2 (p-Ser222), FANCD2 (p-S222) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from HT29 cells treated with CalyculinA using Phospho-FANCD2 (Ser222) antibody TMAC-01439. The lane on the right is treated with the antigen-specific peptide.  |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 222 (G-D-S(p)-Q-H) derived from Human FANCD2 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 166 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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