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Enpp/Carbonic anhydrase-IN-1

Name: Enpp/Carbonic anhydrase-IN-1
Brand: TargetMol
SKU: T67775
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67775Cas No. 2883495-35-8

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells.

Enpp/Carbonic anhydrase-IN-1

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Purity: 99.96%

Catalog No. T67775Cas No. 2883495-35-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$138	In Stock	In Stock
100 mg	$226	In Stock	In Stock
200 mg	$319	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells.
Targets&IC50	NPP3:3 µM, CA IX:1.02 µM, NPP1:1.36 µM, CA II:0.88 µM, NPP2:1.35 µM
In vitro	Enpp/Carbonic anhydrase-IN-1 (0-100 µM; ) inhibits cancer cells growth with IC50s of 0.32, 0.40, 0.40, 0.58, 0.87, 0.96 µM for K-562, RPMI-8226, HT-29, SR, COLO 205, SF-539 cells, respectively. Enpp/Carbonic anhydrase-IN-1 (0-2 µM) exhibits low cytotoxic against normal skin fibroblast cells (F180) and normal breast epithelial cells (HME1) with IC50s of > 50 μM. Enpp/Carbonic anhydrase-IN-1 (0.32 µM, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1].

Chemical Properties

Molecular Weight	411.51
Formula	C₂₃H₂₅NO₄S
Cas No.	2883495-35-8
Smiles	O=C(Nc1ccc(OS(=O)(=O)c2ccccc2)cc1)C12CC3CC(CC(C3)C1)C2
Relative Density.	1.342 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (218.71 mM), Sonication and heating to 50℃ are recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (8.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4301 mL	12.1504 mL	24.3007 mL	121.5037 mL
5 mM	0.4860 mL	2.4301 mL	4.8601 mL	24.3007 mL
10 mM	0.2430 mL	1.2150 mL	2.4301 mL	12.1504 mL
20 mM	0.1215 mL	0.6075 mL	1.2150 mL	6.0752 mL
50 mM	0.0486 mL	0.2430 mL	0.4860 mL	2.4301 mL
100 mM	0.0243 mL	0.1215 mL	0.2430 mL	1.2150 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc