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Enpp/Carbonic anhydrase-IN-1

Catalog No. T67775 CAS 2883495-35-8

Enpp/Carbonic Anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and Carbonic Anhydrase. Enpp/Carbonic Anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic Anhydrase-IN-1 exhibits selective antiproliferative activity for cancer cells.

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Enpp/Carbonic anhydrase-IN-1, CAS 2883495-35-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 538.00
500 mg	In stock	$ 1,150.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 exhibits selective antiproliferative activity for cancer cells.
Targets&IC50	NPP3:3 µM, CA-II:0.88 µM, CA-IX:1.02 µM, NPP1:1.36 µM, NPP2:1.35 µM
In vitro	Enpp/Carbonic anhydrase-IN-1 (0-100 µM; ) inhibits cancer cells growth with IC50s of 0.32, 0.40, 0.40, 0.58, 0.87, 0.96 µM for K-562, RPMI-8226, HT-29, SR, COLO 205, SF-539 cells, respectively. Enpp/Carbonic anhydrase-IN-1 (0-2 µM) exhibits low cytotoxic against normal skin fibroblast cells (F180) and normal breast epithelial cells (HME1) with IC50s of > 50 μM. Enpp/Carbonic anhydrase-IN-1 (0.32 µM, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1].

Molecular Weight	411.51
Formula	C23H25NO4S
CAS No.	2883495-35-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90.0 mg/mL (218.7 mM), ultrasonic and warming and heat to 50°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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Keywords

Enpp/Carbonic anhydrase-IN-1 2883495-35-8 Metabolism PDE Carbonic Anhydrase Enpp/CarbonicanhydraseIN1 inhibitor inhibit

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