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KPT-251

Name: KPT-251
Brand: TargetMol
SKU: T24269
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T24269Cas No. 1388841-50-6

Alias KPT251

KPT-251 is a selective nuclear export inhibitor.

KPT-251

🥰Excellent

Purity: 98.54%

Catalog No. T24269Alias KPT251Cas No. 1388841-50-6

KPT-251 is a selective nuclear export inhibitor.

Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$336	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$361	In Stock

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Batch Information

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Purity:98.54%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	KPT-251 is a selective nuclear export inhibitor.
In vitro	Treatment of Glioblastoma neurosphere cultures with KPT-251 revealed dose-responsive growth inhibition in seven patient-derived GBM lines[1].
In vivo	In a systemic metastasis model, following intracardiac injection of PCb2 cells, 80% (8/10) of controls, 10% (1/10) Selinexor- and 20% (2/10) KPT-251-treated animals developed radiographic evidence of lytic bone lesions. Similarly, after intra-tibial injection, the lytic areas were higher in controls than in Selinexor and KPT-251 groups. Analogously, the serum levels of osteoclast markers (mTRAP and type I collagen fragment, CTX), were significantly higher in controls than in Selinexor- and KPT-251-treated animals. Importantly, overall survival and disease-free survival were significantly higher in Selinexor- and KPT-251-treated animals when compared to controls[2].
Synonyms	KPT251

Chemical Properties

Molecular Weight	375.23
Formula	C₁₄H₇F₆N₅O
Cas No.	1388841-50-6
Smiles	C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C3=NN=CO3)C=N2
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (173.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6650 mL	13.3252 mL	26.6503 mL	133.2516 mL
5 mM	0.5330 mL	2.6650 mL	5.3301 mL	26.6503 mL
10 mM	0.2665 mL	1.3325 mL	2.6650 mL	13.3252 mL
20 mM	0.1333 mL	0.6663 mL	1.3325 mL	6.6626 mL
50 mM	0.0533 mL	0.2665 mL	0.5330 mL	2.6650 mL
100 mM	0.0267 mL	0.1333 mL	0.2665 mL	1.3325 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc