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KPT-251

Name: KPT-251
Brand: TargetMol
SKU: T24269
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24269Cas No. 1388841-50-6

Alias KPT251

KPT-251 is a selective nuclear export inhibitor.

KPT-251

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Purity: 98.54%

Catalog No. T24269Alias KPT251Cas No. 1388841-50-6

KPT-251 is a selective nuclear export inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	In Stock	In Stock
2 mg	$172	In Stock	In Stock
5 mg	$272	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$653	In Stock	-
50 mg	$928	In Stock	-
1 mL x 10 mM (in DMSO)	$298	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.54%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	KPT-251 is a selective nuclear export inhibitor.
In vitro	Treatment of Glioblastoma neurosphere cultures with KPT-251 revealed dose-responsive growth inhibition in seven patient-derived GBM lines[1].
In vivo	In a systemic metastasis model, following intracardiac injection of PCb2 cells, 80% (8/10) of controls, 10% (1/10) Selinexor- and 20% (2/10) KPT-251-treated animals developed radiographic evidence of lytic bone lesions. Similarly, after intra-tibial injection, the lytic areas were higher in controls than in Selinexor and KPT-251 groups. Analogously, the serum levels of osteoclast markers (mTRAP and type I collagen fragment, CTX), were significantly higher in controls than in Selinexor- and KPT-251-treated animals. Importantly, overall survival and disease-free survival were significantly higher in Selinexor- and KPT-251-treated animals when compared to controls[2].
Synonyms	KPT251

Chemical Properties

Molecular Weight	375.23
Formula	C₁₄H₇F₆N₅O
Cas No.	1388841-50-6
Smiles	C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C3=NN=CO3)C=N2
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (173.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6650 mL	13.3252 mL	26.6503 mL	133.2516 mL
5 mM	0.5330 mL	2.6650 mL	5.3301 mL	26.6503 mL
10 mM	0.2665 mL	1.3325 mL	2.6650 mL	13.3252 mL
20 mM	0.1333 mL	0.6663 mL	1.3325 mL	6.6626 mL
50 mM	0.0533 mL	0.2665 mL	0.5330 mL	2.6650 mL
100 mM	0.0267 mL	0.1333 mL	0.2665 mL	1.3325 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc