Shopping Cart

Your shopping cart is currently empty

LCKLSL hydrochloride

Name: LCKLSL hydrochloride
Brand: TargetMol
SKU: T78015
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T78015

LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice.

LCKLSL hydrochloride

😃Good

Purity: 99.31%

Catalog No. T78015

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$372	-	In Stock
25 mg	$689	-	In Stock
50 mg	$979	-	In Stock
100 mg	$1,320	-	In Stock
200 mg	$1,780	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.31%

Appearance:Solid

Color:White

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice.
In vitro	In human retinal microvascular endothelial cells (RMVEC), treatment with LCKLSL hydrochloride (0-2 mg) inhibited the production of fibrinolytic enzymes and suppressed VEGF-induced tPA activity under hypoxic conditions. [1]
In vivo	In two in vivo models of angiogenesis (chicken chorioallantoic membrane and mouse stromal plug assay), the application of LCKLSL hydrochloride showed an inhibitory effect on the angiogenic response. After LCKLSL hydrochloride peptide treatment, the length of blood vessels was significantly shortened. At a dose of 5 μg/mL, LCKLSL hydrochloride peptide significantly reduced the number of branches, junctions, and endpoints of vessels. [1]

Chemical Properties

Molecular Weight	712.34
Formula	C₃₀H₅₈ClN₇O₈S
Smiles	CC(C)C[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)O.Cl
Sequence	Leu-Cys-Lys-Leu-Ser-Leu
Sequence Short	LCKLSL

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8 mg/mL (11.23 mM), Sonication is recommended.

DMSO: 20 mg/mL (28.08 mM), Sonication is recommended.

In Vivo Formulation

Saline: 2 mg/mL (2.81 mM), Solution

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4038 mL	7.0191 mL	14.0382 mL	70.1912 mL
5 mM	0.2808 mL	1.4038 mL	2.8076 mL	14.0382 mL
10 mM	0.1404 mL	0.7019 mL	1.4038 mL	7.0191 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0702 mL	0.3510 mL	0.7019 mL	3.5096 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc