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GDC-0339

Name: GDC-0339
Brand: TargetMol
SKU: T15376
Rating: 4.5 (1 reviews)

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Catalog No. T15376Cas No. 1428569-85-0

GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).

GDC-0339

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Catalog No. T15376Cas No. 1428569-85-0

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks
100 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).
Targets&IC50	Pim2:0.1 nM(Ki), Pim1:0.03 nM(Ki), Pim3:0.02 nM(Ki)
In vitro	GDC-0339 is cytostatic (IC50 of 0.1 μM for MM.1S cells). GDC-0339 treatment shows a constellation of Pim downstream signaling events. Which is consistent with inhibition of Pim kinases[2].
In vivo	GDC-0339 has a half-life of t1/2=0.9 h. GDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is potently in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models [2].

Chemical Properties

Molecular Weight	465.5
Formula	C₂₀H₂₂F₃N₇OS
Cas No.	1428569-85-0
Smiles	Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@H](F)CC1
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1482 mL	10.7411 mL	21.4823 mL	107.4114 mL
5 mM	0.4296 mL	2.1482 mL	4.2965 mL	21.4823 mL
10 mM	0.2148 mL	1.0741 mL	2.1482 mL	10.7411 mL
20 mM	0.1074 mL	0.5371 mL	1.0741 mL	5.3706 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1482 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc