Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1). Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1].
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Description | HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1). Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1]. |
Molecular Weight | 428.53 |
Formula | C26H28N4O2 |
CAS No. | 1066676-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HCAR2 agonist 1 1066676-21-8 inhibitor inhibit