Shopping Cart

Remove All
Your shopping cart is currently empty

Z-FY-CHO

Name: Z-FY-CHO
Brand: TargetMol
SKU: T41236
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41236Cas No. 167498-29-5

Alias Z-Phe-Tyr-CHO

Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.

Z-FY-CHO

🥰Excellent

Purity: 95.88%

Catalog No. T41236Alias Z-Phe-Tyr-CHOCas No. 167498-29-5

Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$83	In Stock
10 mg	$132	In Stock
25 mg	$267	In Stock
50 mg	$480	In Stock
100 mg	$788	In Stock
1 mL x 10 mM (in DMSO)	$91	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:95.88%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
In vitro	Cell death induced by 6-OHDA was reduced using Z-FY-CHO (10 μM, 1 h pretreatment).Z-FY-CHO inhibited the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells.Z-FY-CHO treatment resulted in an increase in LC3-II expression and a decrease in P62 expression was decreased, indicating enhanced autophagic activity. In addition, Z-FY-CHO blocked the activation of caspase-3 and PARP. [1] The radiosensitization of U251 cells was significantly improved by using the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA. Both inhibition and knockdown of cathepsin L in U251 cells enhanced radiation-induced DNA damage and G2/M phase cell cycle arrest. Also, inhibition or knockdown of cathepsin L increased radiation-induced apoptosis as evidenced by elevated Bax levels and decreased Bcl-2 levels. [2]
In vivo	In an ovariectomized mouse model of osteoporosis, intraperitoneal injection of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks was able to dose-dependently reduce bone weight loss.Z-FY-CHO acts as an inhibitor of bone resorption by inhibiting collagen degradation. [3]
Synonyms	Z-Phe-Tyr-CHO

Chemical Properties

Molecular Weight	446.5
Formula	C₂₆H₂₆N₂O₅
Cas No.	167498-29-5
Smiles	[C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=C(O)C=C2)C=O)=O)NC(OCC3=CC=CC=C3)=O
Relative Density.	1.249 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (179.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2396 mL	11.1982 mL	22.3964 mL	111.9821 mL
5 mM	0.4479 mL	2.2396 mL	4.4793 mL	22.3964 mL
10 mM	0.2240 mL	1.1198 mL	2.2396 mL	11.1982 mL
20 mM	0.1120 mL	0.5599 mL	1.1198 mL	5.5991 mL
50 mM	0.0448 mL	0.2240 mL	0.4479 mL	2.2396 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1198 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc