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CNS-Penetrant Compound Library

Catalog No. L5900
  Library Compound List   Excel SDF

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 509 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 509 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L5900)

Publications Cited TargetMol Libraries

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Library Composition

Autophagy (107)
Apoptosis (86)
5-HT Receptor (53)
Dopamine Receptor (40)
Antibacterial (40)
Antibiotic (37)
AChR (32)
Endogenous Metabolite (31)
HIV Protease (27)
Adrenergic Receptor (25)
Sodium Channel (23)
COX (23)
Histamine Receptor (22)
Mitophagy (18)
GABA Receptor (18)
Calcium Channel (16)
DNA/RNA Synthesis (14)
Serotonin Transporter (14)
EGFR (14)
Potassium Channel (12)
iGluR (12)
Reverse Transcriptase (11)
NF-κB (11)
PI3K (11)
c-Kit (11)
Norepinephrine (11)
VEGFR (11)
Ferroptosis (10)
Antifungal (10)
Parasite (10)
HDAC (10)
CDK (9)
GluR (9)
Reactive Oxygen Species (9)
AChE (9)
PDGFR (9)
Influenza Virus (8)
mTOR (8)
FLT (8)
Bcr-Abl (7)
MEK (7)
Beta Amyloid (7)
Dehydrogenase (7)
Estrogen/progestogen Receptor (7)
Nucleoside Antimetabolite/Analog (6)
Monoamine Oxidase (6)
TRP/TRPV Channel (6)
P-gp (6)
c-Fms (6)
SARS-CoV (6)
Topoisomerase (6)
Antifection (6)
Virus Protease (6)
NMDAR (6)
Raf (6)
DNA Alkylator/Crosslinker (6)
PDE (6)
CSF-1R (5)
MAO (5)
Glucocorticoid Receptor (5)
S1P Receptor (5)
P450 (5)
Src (5)
LPL Receptor (5)
Adenosine Receptor (5)
Microtubule Associated (5)
TNF (5)
NOD-like Receptor (NLR) (5)
Transferase (4)
Drug Metabolite (4)
DNA Alkylation (4)
FGFR (4)
LRRK2 (4)
p38 MAPK (4)
HSV (4)
Estrogen Receptor/ERR (4)
MMP (4)
ERK (4)
Antifolate (4)
TGF-beta/Smad (3)
IL Receptor (3)
Interleukin (3)
Carbonic Anhydrase (3)
CaMK (3)
Proton pump (3)
HCV Protease (3)
Opioid Receptor (3)
Molecular Glues (3)
Ligand for E3 Ligase (3)
Epigenetic Reader Domain (3)
Phospholipase (3)
PARP (3)
ALK (3)
PPAR (3)
Neurokinin receptor (3)
Tyrosine Kinases (3)
ATM/ATR (3)
ABC (3)
CRISPR/Cas9 (2)
GPR (2)
PD-1/PD-L1 (2)
STAT (2)
CFTR (2)
AMPK (2)
Akt (2)
Retinoid Receptor (2)
HMG-CoA Reductase (2)
HIF/HIF Prolyl-Hydroxylase (2)
IκB/IKK (2)
S6 Kinase (2)
Decarboxylase (2)
HSP (2)
NOD (2)
Sirtuin (2)
Prostaglandin Receptor (2)
Trk receptor (2)
Proteasome (2)
Hedgehog/Smoothened (2)
DNA-PK (2)
Progesterone Receptor (2)
HBV (2)
Phosphatase (2)
ROCK (2)
Aryl Hydrocarbon Receptor (2)
RAAS (2)
RIP kinase (2)
Gamma-secretase (2)
Ligands for Target Protein for PROTAC (2)
Melatonin Receptor (2)
BTK (2)
Monoamine Transporter (2)
Isocitrate Dehydrogenase (IDH) (2)
BCL (2)
Mitochondrial Metabolism (2)
MRP (2)
ROR (2)
Histone Methyltransferase (2)
OX Receptor (2)
CAT (2)
Vasopressin Receptor (2)
FAAH (2)
DHFR (2)
advanced glycation end products (2)
PAK (2)
NOS (2)
MLK (1)
Adenosine deaminase (1)
HIF (1)
Glutathione Peroxidase (1)
JNK (1)
Hydroxylase (1)
AhR (1)
Mdm2 (1)
SGK (1)
Lipase (1)
Sigma receptor (1)
Complement System (1)
Hydrogenase (1)
Cannabinoid Receptor (1)
NADPH (1)
Arrestin (1)
Syk (1)
BACE (1)
Antioxidant (1)
c-Met/HGFR (1)
DNA Methyltransferase (1)
Ras (1)
Tyrosinase (1)
Integrin (1)
Histone Demethylase (1)
IGF-1R (1)
GSK-3 (1)
BCRP (1)
ROS (1)
Antiviral (1)
Fatty Acid Synthase (1)
JAK (1)
MAPK (1)
Beta-Secretase (1)
Lipid (1)
GlyT (1)
Telomerase (1)
CCR (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Chk (1)
DUB (1)
Epoxide Hydrolase (1)
Aurora Kinase (1)
Free radical scavengers (1)
Histone Acetyltransferase (1)
PDK (1)
IRE1 (1)
Wnt/beta-catenin (1)
Cysteine Protease (1)
Aromatase (1)
Liver X Receptor (1)
Lipoxygenase (1)
PKC (1)
Annexin A (1)
P2X Receptor (1)
E1/E2/E3 Enzyme (1)
GST (1)
LDL (1)
RSV (1)
MT Receptor (1)
Pyroptosis (1)
Nrf2 (1)
Caspase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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