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AG 1295

Name: AG 1295
Brand: TargetMol
SKU: T14137
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14137Cas No. 71897-07-9

AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4].

AG 1295

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Purity: 99.64%

Catalog No. T14137Cas No. 71897-07-9

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$146	In Stock
50 mg	$247	In Stock
100 mg	$372	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Purity:99.64%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4].
In vitro	AG1295 (10 μM, 100 μM) significantly inhibits rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB in vitro[2]. AG 1295 inhibits PDGFR autophosphorylation with IC50s of 0.3-0.5 μM and 0.5-1 μM for membrane autophosphorylation assays and Swiss 3T3 cells, respectively[1].
In vivo	AG-1295 reduces neointimal formation in aortic allograft vasculopathy by inhibiting PDGFR-beta-triggered tyrosine phosphorylation[3]. AG1295 (12 mg/kg; i.p.; daily; for 14 or 21 days) significantly decreases interstitial fibrosis, as evidenced by a smaller Sirius-Red stained area, fewer macrophages, reduced ED-A+ fibronectin deposition, and fewer alpha-smooth muscle actin-positive cells[4].

Chemical Properties

Molecular Weight	234.3
Formula	C₁₆H₁₄N₂
Cas No.	71897-07-9
Smiles	Cc1cc2ncc(nc2cc1C)-c1ccccc1
Relative Density.	1.127 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (256.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2680 mL	21.3402 mL	42.6803 mL	213.4016 mL
5 mM	0.8536 mL	4.2680 mL	8.5361 mL	42.6803 mL
10 mM	0.4268 mL	2.1340 mL	4.2680 mL	21.3402 mL
20 mM	0.2134 mL	1.0670 mL	2.1340 mL	10.6701 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	4.2680 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1340 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc