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Anti-BMI-1 Antibody (9H107)
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Catalog No. TMAY-00110
Anti-BMI-1 Antibody (9H107) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (9H107) can be used in IHC-P.
Anti-BMI-1 Antibody (9H107)
Anti-BMI-1 Antibody (9H107)
😃Good
Catalog No. TMAY-00110
Anti-BMI-1 Antibody (9H107) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (9H107) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-BMI-1 Antibody (9H107) is a Rabbit antibody targeting BMI-1. Anti-BMI-1 Antibody (9H107) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9H107 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human BMI1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human BMI1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Polycomb group member protein BMI1 is involved in maintaining cell identity, proliferation, differentiation and human oncogenesis. BMI1 mRNA expression in whole blood might represent a new biomarker for the diagnosis and prognosis of NSCLC. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model. BMI1 inhibition suppressed proliferation of leukemia cells through NOTCH signaling which functions downstream of BMI1, suggesting that BMI1 inhibitors can be candidate targeted drugs against leukemia. BMI1 decreases ATR activation through a mechanism that involves binding to TOPBP1 and/or ATR. BMI1 over-expression may be useful in identifying patients who might benefit from novel therapies directed at reversing the chromatin-modifying functions of BMI1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the center region of the Human BMI1 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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