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Anti-PEN2 Antibody (6Z374)
Catalog No. TMAB-10170 Copy Product Info
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Anti-PEN2 Antibody (6Z374) is a Rabbit antibody targeting PEN2. Anti-PEN2 Antibody (6Z374) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-PEN2 Antibody (6Z374)
Copy Product Info🥰Excellent
Catalog No. TMAB-10170
Anti-PEN2 Antibody (6Z374) is a Rabbit antibody targeting PEN2. Anti-PEN2 Antibody (6Z374) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-PEN2 Antibody
(6Z374)
(6Z374)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-PEN2 Antibody (6Z374) is a Rabbit antibody targeting PEN2. Anti-PEN2 Antibody (6Z374) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| Clone | 6Z374 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Human Skeletal muscle; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with PEN2 Monoclonal Antibody, Unconjugated (TMAB-10170) at 1: 200 overnight at 4°C, followed by conjugation to the Goat Anti-Rabbit IgG H&L Secondary Antibody-HRP and DAB staining. 2. 25 μg total protein per lane of various lysates (see on figure) probed with PEN2 monoclonal antibody, unconjugated (TMAB-10170) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:100-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi. |
| Tissue Specificity | Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. |
| Immunogen | A synthesized peptide: human PEN 2 |
| Antigen Species | Human |
| Gene Name | PSENEN |
| Gene ID | |
| Protein Name | gamma-secretase subunit PEN-2 |
| Uniprot ID |
| Molecular Weight | Theoretical: 12 kDa. Actual: 13 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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