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Antiproliferative agent-16

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Catalog No. T64348Cas No. 15641-17-5
Alias Antiproliferative agent-16

Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).

Antiproliferative agent-16

Antiproliferative agent-16

🥰Excellent
Purity: 99.10%
Catalog No. T64348Alias Antiproliferative agent-16Cas No. 15641-17-5
Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39-In Stock
5 mg$96-In Stock
10 mg$138-In Stock
25 mg$239-In Stock
50 mg$342-In Stock
100 mg$453-In Stock
200 mg$613-In Stock
1 mL x 10 mM (in DMSO)$89-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.10%
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Product Introduction

Bioactivity
Description
Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).
In vitro
Antiproliferative agent-16 (compound 18f) demonstrated cytotoxicity to DU145, LNCaP, MDA-MB231, MCF7, and PaCa2 cancer cells, with IC50 values of 115.1 μM, 51.63 μM, 300.8 μM, 6.94 μM, and 91.18 μM, respectively [1].
SynonymsAntiproliferative agent-16
Chemical Properties
Molecular Weight277.32
FormulaC17H15N3O
Cas No.15641-17-5
SmilesC(=NNC(CC1=CC=CC=C1)=O)C=2C=3C(NC2)=CC=CC3
Relative Density.1.19 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (180.3 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6059 mL18.0297 mL36.0594 mL180.2971 mL
5 mM0.7212 mL3.6059 mL7.2119 mL36.0594 mL
10 mM0.3606 mL1.8030 mL3.6059 mL18.0297 mL
20 mM0.1803 mL0.9015 mL1.8030 mL9.0149 mL
50 mM0.0721 mL0.3606 mL0.7212 mL3.6059 mL
100 mM0.0361 mL0.1803 mL0.3606 mL1.8030 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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