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Antiproliferative agent-16

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Catalog No. T64348Cas No. 15641-17-5
Alias Antiproliferative agent-16

Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).

Antiproliferative agent-16

Antiproliferative agent-16

🥰Excellent
Purity: 99.10%
Catalog No. T64348Alias Antiproliferative agent-16Cas No. 15641-17-5
Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$96In Stock
10 mg$138In Stock
25 mg$239In Stock
50 mg$342In Stock
100 mg$453In Stock
200 mg$613In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:99.10%
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Product Introduction

Bioactivity
Description
Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells).
In vitro
Antiproliferative agent-16 (compound 18f) demonstrated cytotoxicity to DU145, LNCaP, MDA-MB231, MCF7, and PaCa2 cancer cells, with IC50 values of 115.1 μM, 51.63 μM, 300.8 μM, 6.94 μM, and 91.18 μM, respectively [1].
SynonymsAntiproliferative agent-16
Chemical Properties
Molecular Weight277.32
FormulaC17H15N3O
Cas No.15641-17-5
SmilesC(=NNC(CC1=CC=CC=C1)=O)C=2C=3C(NC2)=CC=CC3
Relative Density.1.19 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (180.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6059 mL18.0297 mL36.0594 mL180.2971 mL
5 mM0.7212 mL3.6059 mL7.2119 mL36.0594 mL
10 mM0.3606 mL1.8030 mL3.6059 mL18.0297 mL
20 mM0.1803 mL0.9015 mL1.8030 mL9.0149 mL
50 mM0.0721 mL0.3606 mL0.7212 mL3.6059 mL
100 mM0.0361 mL0.1803 mL0.3606 mL1.8030 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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