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Anti-Fas/CD95 Antibody-APC (1L304)
🥰Excellent
Catalog No. TMAY-03042A
Anti-Fas/CD95 Antibody-APC (1L304) is a APC-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-APC (1L304) can be used in FCM.
Anti-Fas/CD95 Antibody-APC (1L304)
Anti-Fas/CD95 Antibody-APC (1L304)
🥰Excellent
Catalog No. TMAY-03042A
Anti-Fas/CD95 Antibody-APC (1L304) is a APC-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-APC (1L304) can be used in FCM.
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Fas/CD95 Antibody-APC (1L304) is a APC-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-APC (1L304) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1L304 |
| Reactivity | Mouse |
| Verified Activity | Profile of anti-FAS (CD95) reactivity on mouse splenocytes analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with APC Rabbit anti-FAS(CD95). |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD95 / APO-1 / TNFRSF6 / FAS (rM CD95 / APO-1 / TNFRSF6 / FAS; TMPY-01426; NP_032013.2; Met1-Arg169) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD. |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Mouse CD95 / APO-1 / TNFRSF6 / FAS protein (TMPY-01426) |
| Antigen Species | Mouse |
| Biology Area | Tumor Suppressors |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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