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5'-DEOXYADENOSINE

🥰Excellent
Catalog No. T4971Cas No. 4754-39-6
Alias 5′-dAdo

5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar.

5'-DEOXYADENOSINE

5'-DEOXYADENOSINE

🥰Excellent
Purity: 97.35%
Catalog No. T4971Alias 5′-dAdoCas No. 4754-39-6
5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$31In StockIn Stock
10 mg$48In StockIn Stock
25 mg$85In StockIn Stock
50 mg$127In StockIn Stock
100 mg$187In StockIn Stock
1 mL x 10 mM (in DMSO)$35In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.35%
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Product Introduction

Bioactivity
Description
5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar.
Synonyms5′-dAdo
Chemical Properties
Molecular Weight251.24
FormulaC10H13N5O3
Cas No.4754-39-6
SmilesC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Relative Density.1.93g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 20 mg/mL (79.61 mM), Sonication is recommended.
DMSO: 55 mg/mL (218.91 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.96 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.9803 mL19.9013 mL39.8026 mL199.0129 mL
5 mM0.7961 mL3.9803 mL7.9605 mL39.8026 mL
10 mM0.3980 mL1.9901 mL3.9803 mL19.9013 mL
20 mM0.1990 mL0.9951 mL1.9901 mL9.9506 mL
50 mM0.0796 mL0.3980 mL0.7961 mL3.9803 mL
DMSO
1mg5mg10mg50mg
100 mM0.0398 mL0.1990 mL0.3980 mL1.9901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OrthopoxvirusInhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolite5'-Deoxyadenosine5'-DEOXYADENOSINE5'DEOXYADENOSINE5' DEOXYADENOSINE
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