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GPR120 Agonist 4
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Catalog No. T86518Cas No. 1628641-89-3
GPR120 Agonist 4 (example 1), a GPR120 agonist, exhibits EC50 values of 1 μM for β-arrestin A and 0.35 μM for Calcium A. This compound is utilized in research related to type II diabetes mellitus [1].
GPR120 Agonist 4
😃Good
Catalog No. T86518Cas No. 1628641-89-3
GPR120 Agonist 4 (example 1), a GPR120 agonist, exhibits EC50 values of 1 μM for β-arrestin A and 0.35 μM for Calcium A. This compound is utilized in research related to type II diabetes mellitus [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GPR120 Agonist 4 (example 1), a GPR120 agonist, exhibits EC50 values of 1 μM for β-arrestin A and 0.35 μM for Calcium A. This compound is utilized in research related to type II diabetes mellitus [1]. |
| Targets&IC50 | GPR120:1 μM (EC 50 ) |
| In vitro | GPR120 Agonist 4 (example 1), at concentrations of 0.012-25 μM over 90 minutes, activates GPR120 in CHO-K1 GPR120 β-arrestin cells through the recruitment of β-arrestin [1]. Additionally, GPR120 Agonist 4 (0.012-25 μM, 90 min) facilitates calcium ion release in HEK293 cells overexpressing human GPR120, confirming its effectiveness in activating GPR120 [1]. |
| In vivo | GPR120 Agonist 4 (example 1), administered intraperitoneally at doses of 0.2/0.3/1/3/10 mg/kg for 15/30/45/60/90 minutes, promotes a dose-dependent reduction in glucose levels in a high-fat diet mouse model [1]. Furthermore, at doses of 1/3/10 mg/kg for the same time intervals, it inhibits the rise in glucose levels in a fasting mouse model in a dose-dependent manner [1]. |
| Molecular Weight | 459.79 |
| Formula | C21H15ClF5NO3 |
| Cas No. | 1628641-89-3 |
| Smiles | C(OC1=C(F)C=C(CCC(O)=O)C=C1F)C=2N(C=CC2C(F)(F)F)C3=CC=C(Cl)C=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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