Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor. |
In vivo | WHI-P180 acts as an effective inhibitor of IgE-mediated mast cell responses. In CD-1 (BALB/c) mice, its elimination half-life is below 10 minutes across intravenous (i.v.), intraperitoneal (i.p.), and oral (p.o.) administrations. Systemic clearance rates for WHI-P180 are recorded at 6742 mL/h/kg in CD-1 mice and 8188 mL/h/kg in BALB/c mice. Importantly, administering two consecutive, non-toxic i.p. bolus doses of 25 mg/kg of WHI-P180 suppresses IgE/antigen-induced vascular hyperpermeability in a validated mouse model of passive cutaneous anaphylaxis. |
Molecular Weight | 333.77 |
Formula | C16H16ClN3O3 |
CAS No. | 153437-55-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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WHI-P180 hydrochloride 153437-55-9 inhibitor inhibit