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Toyocamycin

Name: Toyocamycin
Brand: TargetMol
SKU: T17143
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17143Cas No. 606-58-6

Alias Vengicide

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycetes, functioning as an XBP1 inhibitor and inhibiting IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM), and induces apoptosis.

Toyocamycin

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Purity: 99.44%

Catalog No. T17143Alias VengicideCas No. 606-58-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$115	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$372	-	In Stock
500 mg	$869	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Color:White

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Product Introduction

Toyocamycin AI Summary

Toyocamycin exhibits a broad spectrum of bioactivities, including antiviral, cytotoxic, antiproliferative, and enzyme inhibition properties. It demonstrates potent antiviral effects against various viruses, such as human cytomegalovirus (IC50 50.0 nM in a plaque reduction assay), herpes simplex virus (IC50 29000.0 nM in a plaque reduction assay), and SARS-CoV-2 (inhibition of cytotoxicity in VERO-6 cells by 11.99% at a 10 µM concentration). This compound also shows significant cytotoxicity across several cell lines, including human prostate cancer cells (EC50 12.0 nM), B16 mouse melanoma cells (EC50 5.0 nM), and normal human fibroblast cells (EC50 4.0 nM). In the realm of antiproliferative activity, it inhibits the proliferation of L1210 murine leukemic cells (IC50 4.0 nM) and KB cells (IC50 30.0 nM). Moreover, Toyocamycin inhibits human adenosine kinase (IC50 310.0 nM), human HDAC6 (14.49% inhibition at 20 µM), and phosphatidylinositol 4-kinase in human A431 cell membrane (IC50 3.3 µg/mL). Additionally, it displays antifungal activity against Candida albicans and a measurable binding affinity to human truncated HSC70 NBD protein. The compound's multifaceted bioactivities highlight its potential therapeutic implications across various medical fields..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycetes, functioning as an XBP1 inhibitor and inhibiting IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM), and induces apoptosis.
Targets&IC50	CDK6-CyclinD3:>10 μM, CDK9-CyclinT1:79 nM, XBP1:80 nM, CDK2-CyclinA:0.67 μM, CDK4-CyclinD3:15 μM, CDK7-CyclinH-MAT1:2.8 μM
Synonyms	Vengicide

Chemical Properties

Molecular Weight	291.26
Formula	C₁₂H₁₃N₅O₄
Cas No.	606-58-6
Smiles	Nc1ncnc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Relative Density.	1.91g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122.5 mg/mL (420.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4334 mL	17.1668 mL	34.3336 mL	171.6679 mL
5 mM	0.6867 mL	3.4334 mL	6.8667 mL	34.3336 mL
10 mM	0.3433 mL	1.7167 mL	3.4334 mL	17.1668 mL
20 mM	0.1717 mL	0.8583 mL	1.7167 mL	8.5834 mL
50 mM	0.0687 mL	0.3433 mL	0.6867 mL	3.4334 mL
100 mM	0.0343 mL	0.1717 mL	0.3433 mL	1.7167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Toyocamycin

Toyocamycin

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