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MPO-IN-1

Name: MPO-IN-1
Brand: TargetMol
SKU: T40137
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40137Cas No. 2471981-21-0

MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.

MPO-IN-1

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Purity: 99.27%

Catalog No. T40137Cas No. 2471981-21-0

MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.

Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$281	In Stock
10 mg	$493	In Stock
25 mg	$1,020	In Stock
1 mL x 10 mM (in DMSO)	$316	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.27%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.
Targets&IC50	MPO:2.6 μM
In vitro	MPO-IN-1 is an irreversible indole-containing myeloperoxidase (MPO) inhibitor with an IC50 of 2.6 μM. [1]
In vivo	The plasma concentration of mice was reduced in a biphasic manner after intravenous administration of MPO-IN-1 (1 mg/kg). The mean plasma elimination half-life (T1/2) was 2.6 h. Mpo-in-1 (5 mg/kg or 90 mg/kg orally) causes up-regulation of MPO activity IN the coated exudate in mice. [1]

Chemical Properties

Molecular Weight	400.9
Formula	C₂₄H₂₁ClN₄
Cas No.	2471981-21-0
Smiles	ClC=1C=CN=C2C1C(=CN2C3=CC=C(C=C3)CN(C)C)C=4C=CC=5C=CNC5C4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (399.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4944 mL	12.4719 mL	24.9439 mL	124.7194 mL
5 mM	0.4989 mL	2.4944 mL	4.9888 mL	24.9439 mL
10 mM	0.2494 mL	1.2472 mL	2.4944 mL	12.4719 mL
20 mM	0.1247 mL	0.6236 mL	1.2472 mL	6.2360 mL
50 mM	0.0499 mL	0.2494 mL	0.4989 mL	2.4944 mL
100 mM	0.0249 mL	0.1247 mL	0.2494 mL	1.2472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc