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BB-Cl-Amidine hydrochloride

Name: BB-Cl-Amidine hydrochloride
Brand: TargetMol
SKU: T10482L
Rating: 4.5 (1 reviews)

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Catalog No. T10482LCas No. 2436747-41-8

Alias BB-Cl-Amidine hydrochloride (1802637-39-3 free base)

BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].

BB-Cl-Amidine hydrochloride

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Catalog No. T10482LAlias BB-Cl-Amidine hydrochloride (1802637-39-3 free base)Cas No. 2436747-41-8

BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].

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Product Introduction

Bioactivity

Description	BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].
In vivo	Treatment with BB-Cl-amidine modestly reduces splenomegaly in MRL/lpr mice and trends towards an increase in circulating anti-NET antibodies when treated with PAD inhibitors. However, PAD inhibitors do not impact body weight or total IgG levels. Notably, both Cl-amidine and BB-Cl-amidine treatments significantly enhance endothelium-dependent vasorelaxation, with BB-Cl-amidine also displaying a pronounced trend towards IRG downregulation. Furthermore, either compound significantly ameliorates muzzle alopecia, often preventing it entirely. This study involved subcutaneous injection of 1 mg/kg doses administered daily to MRL/lpr mice aged 8 to 14 weeks, resulting in markedly improved vasorelaxation and a strong IRG downregulation trend.
Synonyms	BB-Cl-Amidine hydrochloride (1802637-39-3 free base)

Chemical Properties

Molecular Weight	496.43
Formula	C₂₆H₂₇Cl₂N₅O
Cas No.	2436747-41-8
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (201.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.65 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0144 mL	10.0719 mL	20.1438 mL	100.7191 mL
5 mM	0.4029 mL	2.0144 mL	4.0288 mL	20.1438 mL
10 mM	0.2014 mL	1.0072 mL	2.0144 mL	10.0719 mL
20 mM	0.1007 mL	0.5036 mL	1.0072 mL	5.0360 mL
50 mM	0.0403 mL	0.2014 mL	0.4029 mL	2.0144 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	1.0072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc