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BB-Cl-Amidine hydrochloride

Name: BB-Cl-Amidine hydrochloride
Brand: TargetMol
SKU: T10482L
Rating: 4.5 (1 reviews)

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Catalog No. T10482LCas No. 2436747-41-8

Alias BB-Cl-Amidine hydrochloride (1802637-39-3 free base)

BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].

BB-Cl-Amidine hydrochloride

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Catalog No. T10482LAlias BB-Cl-Amidine hydrochloride (1802637-39-3 free base)Cas No. 2436747-41-8

BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].

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Product Introduction

Bioactivity

Description	BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].
In vivo	Treatment with BB-Cl-amidine modestly reduces splenomegaly in MRL/lpr mice and trends towards an increase in circulating anti-NET antibodies when treated with PAD inhibitors. However, PAD inhibitors do not impact body weight or total IgG levels. Notably, both Cl-amidine and BB-Cl-amidine treatments significantly enhance endothelium-dependent vasorelaxation, with BB-Cl-amidine also displaying a pronounced trend towards IRG downregulation. Furthermore, either compound significantly ameliorates muzzle alopecia, often preventing it entirely. This study involved subcutaneous injection of 1 mg/kg doses administered daily to MRL/lpr mice aged 8 to 14 weeks, resulting in markedly improved vasorelaxation and a strong IRG downregulation trend.
Synonyms	BB-Cl-Amidine hydrochloride (1802637-39-3 free base)

Chemical Properties

Molecular Weight	496.43
Formula	C₂₆H₂₇Cl₂N₅O
Cas No.	2436747-41-8
Smiles	O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=CC=CC=C4N3)CCCNC(CCl)=N.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (201.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0144 mL	10.0719 mL	20.1438 mL	100.7191 mL
5 mM	0.4029 mL	2.0144 mL	4.0288 mL	20.1438 mL
10 mM	0.2014 mL	1.0072 mL	2.0144 mL	10.0719 mL
20 mM	0.1007 mL	0.5036 mL	1.0072 mL	5.0360 mL
50 mM	0.0403 mL	0.2014 mL	0.4029 mL	2.0144 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	1.0072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc