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Anti-B2M/beta 2-Microglobulin Antibody (8Y711)
🥰Excellent
Catalog No. TMAY-02182
Anti-B2M/beta 2-Microglobulin Antibody (8Y711) is a Rabbit antibody targeting B2M/beta 2-Microglobulin. Anti-B2M/beta 2-Microglobulin Antibody (8Y711) can be used in IHC-P,ICC/IF.
Anti-B2M/beta 2-Microglobulin Antibody (8Y711)
Anti-B2M/beta 2-Microglobulin Antibody (8Y711)
🥰Excellent
Catalog No. TMAY-02182
Anti-B2M/beta 2-Microglobulin Antibody (8Y711) is a Rabbit antibody targeting B2M/beta 2-Microglobulin. Anti-B2M/beta 2-Microglobulin Antibody (8Y711) can be used in IHC-P,ICC/IF.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-B2M/beta 2-Microglobulin Antibody (8Y711) is a Rabbit antibody targeting B2M/beta 2-Microglobulin. Anti-B2M/beta 2-Microglobulin Antibody (8Y711) can be used in IHC-P,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8Y711 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human B2M in human ovarian cancer (from 2 donors) with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human B2M in human esophageal carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunofluorescence staining of Human B2M in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human B2M monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| Application | IHC-P,ICC/IF |
| Recommended Dose | IHC-P: 1:100-1:500; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human B2M / beta-2 microglobulin (rh B2M / beta-2 microglobulin; TMPY-01686; NP_004039.1; Met1-Met119). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M (β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M (β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens. B2M (β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to the α3 chain. Unlike α3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M (β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M (β2 microglobulin) can indicate non-progression of HIV. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human B2M / beta-2 microglobulin protein (TMPY-01686) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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