Siomycin A

Name: Siomycin A
Brand: TargetMol
SKU: T12917
Rating: 4.5 (1 reviews)

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Catalog No. T12917Cas No. 12656-09-6

Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.

Siomycin A

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Catalog No. T12917Cas No. 12656-09-6

Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$990	35 days	35 days

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Product Introduction

Bioactivity

Description	Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.
In vitro	cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells markedly reduced by Siomycin A (0-10 μM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells). Among the three cell lines(IC50 of the human leukemia K562 cells is the lowest at 6.25 μM at 24 h), while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 μM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 μM, respectively[1]. Siomycin A (0-10 μM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells[1]. Siomycin A (0-10 μM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells[1].
In vivo	In vivo mouse model,Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth [2].

Chemical Properties

Molecular Weight	1648.84
Formula	C₇₁H₈₁N₁₉O₁₈S₅
Cas No.	12656-09-6
Smiles	[H][C@]12CSC(=N1)C(NC(=O)C(NC(=O)c1csc(n1)[C@@]13CCC(=N[C@]1([H])c1csc(n1)[C@@]([H])(NC(=O)c1csc(n1)[C@@]([H])(NC2=O)[C@](C)(O)[C@@H](C)O)[C@@H](C)OC(=O)c1cc([C@H](C)O)c2C=C[C@@H](N[C@@H](C(C)C)C(=O)NC(=C)C(=O)NC(=C)C(=O)N[C@@H](C)C(=O)N3)[C@@]([H])(O)c2n1)c1nc(cs1)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)[C@@H](C)O)=CC \|c:4,24,70\|
Relative Density.	1.65 g/cm3 (Predicted)

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc